Table of Contents  

Nutrition and exercise in the treatment of type 2 diabetes mellitus

Subash Sivaraman, Martin O. Weickert
Published in : HAMDAN MEDICAL JOURNAL ; Vol 5, No 2 (2012)
DOI : 10.7707/hmj.v5i2.136

Abstract


Dietary factors and insufficient exercise levels are now presumed to be the leading cause of chronic disease worldwide. Insulin resistance due to chronic energy-dense food intake combined with lack of physical activity has been proposed as the strongest single predictor for the development of type 2 diabetes mellitus (T2DM). Conversely, a healthy diet in conjunction with exercise causes weight loss and reduces abdominal fat mass and insulin resistance. Furthermore, modulating the macronutrient composition of isoenergetic foods appears to have additional important effects on insulin sensitivity and diabetes risk, concepts that are of particular interest given that long-term sustained weight loss is difficult to achieve. We here provide an update of the current literature regarding the role of nutrition and exercise in the prevention and treatment of T2DM, with a focus on currently used concepts and controversies regarding modulation of glucose metabolism and diabetes risk using lifestyle measures.



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References


Neal B: White rice and risk of type 2 diabetes. Bmj 2012 344 e2021.

Narayan KM, Boyle JP, Thompson TJ, Sorensen SW & Williamson DF: Lifetime risk for diabetes mellitus in the United States. Jama 2003 290 1884-1890.

Colberg SR, Sigal RJ, Fernhall B, Regensteiner JG, Blissmer BJ, Rubin RR, Chasan-Taber L, Albright AL & Braun B: Exercise and type 2 diabetes: the American College of Sports Medicine and the American Diabetes Association: joint position statement. Diabetes Care 2010 33 e147-167.

McAuley K & Mann J: Thematic review series: patient-oriented research. Nutritional determinants of insulin resistance. J Lipid Res 2006 47 1668-1676.

Vazquez G, Duval S, Jacobs DR, Jr. & Silventoinen K: Comparison of body mass index, waist circumference, and waist/hip ratio in predicting incident diabetes: a meta-analysis. Epidemiol Rev 2007 29 115-128.

Sung KC, Jeong WS, Wild SH & Byrne CD: Combined influence of insulin resistance, overweight/obesity, and Fatty liver as risk factors for type 2 diabetes. Diabetes Care 2012 35 717-722.

Kastorini CM, Milionis HJ, Esposito K, Giugliano D, Goudevenos JA & Panagiotakos DB: The effect of Mediterranean diet on metabolic syndrome and its components: a meta-analysis of 50 studies and 534,906 individuals. J Am Coll Cardiol 2011 57 1299-1313.

Riserus U, Willett WC & Hu FB: Dietary fats and prevention of type 2 diabetes. Prog Lipid Res 2009 48 44-51.

Thomas T & Pfeiffer AF: Foods for the prevention of diabetes: how do they work? Diabetes Metab Res Rev 2011 28 25-49.

Weickert MO & Pfeiffer AF: Metabolic effects of dietary fiber consumption and prevention of diabetes. J Nutr 2008 138 439-442.

Brand-Miller J, McMillan-Price J, Steinbeck K & Caterson I: Dietary glycemic index: health implications. J Am Coll Nutr 2009 28 Suppl 446S-449S.

de Munter JS, Hu FB, Spiegelman D, Franz M & van Dam RM: Whole grain, bran, and germ intake and risk of type 2 diabetes: a prospective cohort study and systematic review. PLoS Med 2007 4 e261.

Schulze MB, Schulz M, Heidemann C, Schienkiewitz A, Hoffmann K & Boeing H: Fiber and magnesium intake and incidence of type 2 diabetes: a prospective study and meta-analysis. Arch Intern Med 2007 167 956-965.

Rassool GH: Expert report on diet, nutrition and prevention of chronic diseases. J Adv Nurs 2003 43 544-545.

Zisser H, Gong P, Kelley CM, Seidman JS & Riddell MC: Exercise and diabetes. Int J Clin Pract Suppl 2011 71-75.

Morrato EH, Hill JO, Wyatt HR, Ghushchyan V & Sullivan PW: Physical activity in U.S. adults with diabetes and at risk for developing diabetes, 2003. Diabetes Care 2007 30 203-209.

ADA: Standards of medical care in diabetes--2011. Diabetes Care 2011 34 Suppl 1 S11-61.

Gomez-Cabrera MC, Ristow M & Vina J: Antioxidant supplements in exercise: worse than useless? Am J Physiol Endocrinol Metab 2012 302 E476-477; author reply E478-479.

Brancati FL, Wang NY, Mead LA, Liang KY & Klag MJ: Body weight patterns from 20 to 49 years of age and subsequent risk for diabetes mellitus: the Johns Hopkins Precursors Study. Arch Intern Med 1999 159 957-963.

Kelley DE, Wing R, Buonocore C, Sturis J, Polonsky K & Fitzsimmons M: Relative effects of calorie restriction and weight loss in noninsulin-dependent diabetes mellitus. J Clin Endocrinol Metab 1993 77 1287-1293.

Wing RR, Koeske R, Epstein LH, Nowalk MP, Gooding W & Becker D: Long-term effects of modest weight loss in type II diabetic patients. Arch Intern Med 1987 147 1749-1753.

Maggio CA & Pi-Sunyer FX: The prevention and treatment of obesity. Application to type 2 diabetes. Diabetes Care 1997 20 1744-1766.

Pi-Sunyer FX: Weight loss in type 2 diabetic patients. Diabetes Care 2005 28 1526-1527.

Milne RM, Mann JI, Chisholm AW & Williams SM: Long-term comparison of three dietary prescriptions in the treatment of NIDDM. Diabetes Care 1994 17 74-80.

Sacks FM, Bray GA, Carey VJ, Smith SR, Ryan DH, Anton SD, McManus K, Champagne CM, Bishop LM, Laranjo N, Leboff MS, Rood JC, de Jonge L, Greenway FL, Loria CM, Obarzanek E & Williamson DA: Comparison of weight-loss diets with different compositions of fat, protein, and carbohydrates. N Engl J Med 2009 360 859-873.

Dansinger ML, Gleason JA, Griffith JL, Selker HP & Schaefer EJ: Comparison of the Atkins, Ornish, Weight Watchers, and Zone diets for weight loss and heart disease risk reduction: a randomized trial. Jama 2005 293 43-53.

Redmon JB, Reck KP, Raatz SK, Swanson JE, Kwong CA, Ji H, Thomas W & Bantle JP: Two-year outcome of a combination of weight loss therapies for type 2 diabetes. Diabetes Care 2005 28 1311-1315.

Hession M, Rolland C, Kulkarni U, Wise A & Broom J: Systematic review of randomized controlled trials of low-carbohydrate vs. low-fat/low-calorie diets in the management of obesity and its comorbidities. Obes Rev 2009 10 36-50.

Bray GA: Effect of caloric restriction on energy expenditure in obese patients. Lancet 1969 2 397-398.

Heshka S, Yang MU, Wang J, Burt P & Pi-Sunyer FX: Weight loss and change in resting metabolic rate. Am J Clin Nutr 1990 52 981-986.

Bogardus C, Taskinen MR, Zawadzki J, Lillioja S, Mott D & Howard BV: Increased resting metabolic rates in obese subjects with non-insulin-dependent diabetes mellitus and the effect of sulfonylurea therapy. Diabetes 1986 35 1-5.

Nair KS, Halliday D & Garrow JS: Increased energy expenditure in poorly controlled Type 1 (insulin-dependent) diabetic patients. Diabetologia 1984 27 13-16.

Boule NG, Haddad E, Kenny GP, Wells GA & Sigal RJ: Effects of exercise on glycemic control and body mass in type 2 diabetes mellitus: a meta-analysis of controlled clinical trials. Jama 2001 286 1218-1227.

Larsen TM, Dalskov SM, van Baak M, Jebb SA, Papadaki A, Pfeiffer AF, Martinez JA, Handjieva-Darlenska T, Kunesova M, Pihlsgard M, Stender S, Holst C, Saris WH & Astrup A: Diets with high or low protein content and glycemic index for weight-loss maintenance. N Engl J Med 2010 363 2102-2113.

Beavers KM, Lyles MF, Davis CC, Wang X, Beavers DP & Nicklas BJ: Is lost lean mass from intentional weight loss recovered during weight regain in postmenopausal women? Am J Clin Nutr 2011 94 767-774.

Vessby B, Uusitupa M, Hermansen K, Riccardi G, Rivellese AA, Tapsell LC, Nalsen C, Berglund L, Louheranta A, Rasmussen BM, Calvert GD, Maffetone A, Pedersen E, Gustafsson IB & Storlien LH: Substituting dietary saturated for monounsaturated fat impairs insulin sensitivity in healthy men and women: The KANWU Study. Diabetologia 2001 44 312-319.

Salmeron J, Hu FB, Manson JE, Stampfer MJ, Colditz GA, Rimm EB & Willett WC: Dietary fat intake and risk of type 2 diabetes in women. Am J Clin Nutr 2001 73 1019-1026.

Mozaffarian D: Trans fatty acids - effects on systemic inflammation and endothelial function. Atheroscler Suppl 2006 7 29-32.

Cascio G, Schiera G & Di Liegro I: Dietary fatty acids in metabolic syndrome, diabetes and cardiovascular diseases. Curr Diabetes Rev 2012 8 2-17.

Laaksonen DE, Lakka TA, Lakka HM, Nyyssonen K, Rissanen T, Niskanen LK & Salonen JT: Serum fatty acid composition predicts development of impaired fasting glycaemia and diabetes in middle-aged men. Diabet Med 2002 19 456-464.

Vessby B, Aro A, Skarfors E, Berglund L, Salminen I & Lithell H: The risk to develop NIDDM is related to the fatty acid composition of the serum cholesterol esters. Diabetes 1994 43 1353-1357.

Riccardi G, Giacco R & Rivellese AA: Dietary fat, insulin sensitivity and the metabolic syndrome. Clin Nutr 2004 23 447-456.

Rioux V & Legrand P: Saturated fatty acids: simple molecular structures with complex cellular functions. Curr Opin Clin Nutr Metab Care 2007 10 752-758.

Salas-Salvado J, Martinez-Gonzalez MA, Bullo M & Ros E: The role of diet in the prevention of type 2 diabetes. Nutr Metab Cardiovasc Dis 2011 21 Suppl 2 B32-48.

Isken F, Klaus S, Petzke KJ, Loddenkemper C, Pfeiffer AF & Weickert MO: Impairment of fat oxidation under high- vs. low-glycemic index diet occurs before the development of an obese phenotype. Am J Physiol Endocrinol Metab 2010 298 E287-295.

Pi-Sunyer X: Do glycemic index, glycemic load, and fiber play a role in insulin sensitivity, disposition index, and type 2 diabetes? Diabetes Care 2005 28 2978-2979.

Weickert MO & Pfeiffer AF: Low-glycemic index vs high-cereal fiber diet in type 2 diabetes. Jama 2009 301 1538; author reply 1538-1539.

Weickert MO, Arafat AM, Blaut M, Alpert C, Becker N, Leupelt V, Rudovich N, Mohlig M & Pfeiffer AF: Changes in dominant groups of the gut microbiota do not explain cereal-fiber induced improvement of whole-body insulin sensitivity. Nutr Metab (Lond) 2011 8 90.

Jenkins DJ, Kendall CW, Axelsen M, Augustin LS & Vuksan V: Viscous and nonviscous fibres, nonabsorbable and low glycaemic index carbohydrates, blood lipids and coronary heart disease. Curr Opin Lipidol 2000 11 49-56.

Chandalia M, Garg A, Lutjohann D, von Bergmann K, Grundy SM & Brinkley LJ: Beneficial effects of high dietary fiber intake in patients with type 2 diabetes mellitus. N Engl J Med 2000 342 1392-1398.

Delzenne NM & Cani PD: Gut microbiota and the pathogenesis of insulin resistance. Curr Diab Rep 2011 11 154-159.

Freeland KR, Wilson C & Wolever TM: Adaptation of colonic fermentation and glucagon-like peptide-1 secretion with increased wheat fibre intake for 1 year in hyperinsulinaemic human subjects. Br J Nutr 2010 103 82-90.

Pereira MA, Jacobs DR, Jr., Pins JJ, Raatz SK, Gross MD, Slavin JL & Seaquist ER: Effect of whole grains on insulin sensitivity in overweight hyperinsulinemic adults. Am J Clin Nutr 2002 75 848-855.

Weickert MO, Roden M, Isken F, Hoffmann D, Nowotny P, Osterhoff M, Blaut M, Alpert C, Gogebakan O, Bumke-Vogt C, Mueller F, Machann J, Barber TM, Petzke KJ, Hierholzer J, Hornemann S, Kruse M, Illner AK, Kohl A, Loeffelholz CV, Arafat AM, Mohlig M & Pfeiffer AF: Effects of supplemented isoenergetic diets differing in cereal fiber and protein content on insulin sensitivity in overweight humans. Am J Clin Nutr 2011 94 459-471.

Tremblay F, Krebs M, Dombrowski L, Brehm A, Bernroider E, Roth E, Nowotny P, Waldhausl W, Marette A & Roden M: Overactivation of S6 kinase 1 as a cause of human insulin resistance during increased amino acid availability. Diabetes 2005 54 2674-2684.

Um SH, D'Alessio D & Thomas G: Nutrient overload, insulin resistance, and ribosomal protein S6 kinase 1, S6K1. Cell Metab 2006 3 393-402.

Malik VS & Hu FB: Popular weight-loss diets: from evidence to practice. Nat Clin Pract Cardiovasc Med 2007 4 34-41.

Gosby AK, Conigrave AD, Lau NS, Iglesias MA, Hall RM, Jebb SA, Brand-Miller J, Caterson ID, Raubenheimer D & Simpson SJ: Testing protein leverage in lean humans: a randomised controlled experimental study. PLoS One 2011 6 e25929.

Sluijs I, Beulens JW, van der AD, Spijkerman AM, Grobbee DE & van der Schouw YT: Dietary intake of total, animal, and vegetable protein and risk of type 2 diabetes in the European Prospective Investigation into Cancer and Nutrition (EPIC)-NL study. Diabetes Care 2010 33 43-48.

Gogebakan O, Kohl A, Osterhoff MA, van Baak MA, Jebb SA, Papadaki A, Martinez JA, Handjieva-Darlenska T, Hlavaty P, Weickert MO, Holst C, Saris WH, Astrup A & Pfeiffer AF: Effects of weight loss and long-term weight maintenance with diets varying in protein and glycemic index on cardiovascular risk factors: the diet, obesity, and genes (DiOGenes) study: a randomized, controlled trial. Circulation 2011 124 2829-2838.

Linn T, Santosa B, Gronemeyer D, Aygen S, Scholz N, Busch M & Bretzel RG: Effect of long-term dietary protein intake on glucose metabolism in humans. Diabetologia 2000 43 1257-1265.

Brand-Miller JC, Griffin HJ & Colagiuri S: The carnivore connection hypothesis: revisited. J Obes 2012 2012 258624.

Chen L, Magliano DJ & Zimmet PZ: The worldwide epidemiology of type 2 diabetes mellitus-present and future perspectives. Nat Rev Endocrinol 2012 8 228-236.

Services UDoHaH: Physical activity guidelines for Americans. Okla Nurse 2008 53 25.

Reis JP, Loria CM, Sorlie PD, Park Y, Hollenbeck A & Schatzkin A: Lifestyle factors and risk for new-onset diabetes: a population-based cohort study. Ann Intern Med 2011 155 292-299.

Hu FB, Li TY, Colditz GA, Willett WC & Manson JE: Television watching and other sedentary behaviors in relation to risk of obesity and type 2 diabetes mellitus in women. Jama 2003 289 1785-1791.

Krishnan S, Rosenberg L & Palmer JR: Physical activity and television watching in relation to risk of type 2 diabetes: the Black Women's Health Study. Am J Epidemiol 2009 169 428-434.

Engberg S, Glumer C, Witte DR, Jorgensen T & Borch-Johnsen K: Differential relationship between physical activity and progression to diabetes by glucose tolerance status: the Inter99 Study. Diabetologia 2010 53 70-78.

Dempsey JC, Butler CL, Sorensen TK, Lee IM, Thompson ML, Miller RS, Frederick IO & Williams MA: A case-control study of maternal recreational physical activity and risk of gestational diabetes mellitus. Diabetes Res Clin Pract 2004 66 203-215.

Balducci S, Iacobellis G, Parisi L, Di Biase N, Calandriello E, Leonetti F & Fallucca F: Exercise training can modify the natural history of diabetic peripheral neuropathy. J Diabetes Complications 2006 20 216-223.

Cohen ND, Dunstan DW, Robinson C, Vulikh E, Zimmet PZ & Shaw JE: Improved endothelial function following a 14-month resistance exercise training program in adults with type 2 diabetes. Diabetes Res Clin Pract 2008 79 405-411.

Ghosh S, Khazaei M, Moien-Afshari F, Ang LS, Granville DJ, Verchere CB, Dunn SR, McCue P, Mizisin A, Sharma K & Laher I: Moderate exercise attenuates caspase-3 activity, oxidative stress, and inhibits progression of diabetic renal disease in db/db mice. Am J Physiol Renal Physiol 2009 296 F700-708.

Howorka K, Pumprla J, Haber P, Koller-Strametz J, Mondrzyk J & Schabmann A: Effects of physical training on heart rate variability in diabetic patients with various degrees of cardiovascular autonomic neuropathy. Cardiovasc Res 1997 34 206-214.

Loimaala A, Huikuri HV, Koobi T, Rinne M, Nenonen A & Vuori I: Exercise training improves baroreflex sensitivity in type 2 diabetes. Diabetes 2003 52 1837-1842.

Pagkalos M, Koutlianos N, Kouidi E, Pagkalos E, Mandroukas K & Deligiannis A: Heart rate variability modifications following exercise training in type 2 diabetic patients with definite cardiac autonomic neuropathy. Br J Sports Med 2008 42 47-54.

Tufescu A, Kanazawa M, Ishida A, Lu H, Sasaki Y, Ootaka T, Sato T & Kohzuki M: Combination of exercise and losartan enhances renoprotective and peripheral effects in spontaneously type 2 diabetes mellitus rats with nephropathy. J Hypertens 2008 26 312-321.

Zoppini G, Targher G, Zamboni C, Venturi C, Cacciatori V, Moghetti P & Muggeo M: Effects of moderate-intensity exercise training on plasma biomarkers of inflammation and endothelial dysfunction in older patients with type 2 diabetes. Nutr Metab Cardiovasc Dis 2006 16 543-549.

Cuff DJ, Meneilly GS, Martin A, Ignaszewski A, Tildesley HD & Frohlich JJ: Effective exercise modality to reduce insulin resistance in women with type 2 diabetes. Diabetes Care 2003 26 2977-2982.

Sigal RJ, Kenny GP, Boule NG, Wells GA, Prud'homme D, Fortier M, Reid RD, Tulloch H, Coyle D, Phillips P, Jennings A & Jaffey J: Effects of aerobic training, resistance training, or both on glycemic control in type 2 diabetes: a randomized trial. Ann Intern Med 2007 147 357-369.

Balducci S, Zanuso S, Nicolucci A, Fernando F, Cavallo S, Cardelli P, Fallucca S, Alessi E, Letizia C, Jimenez A, Fallucca F & Pugliese G: Anti-inflammatory effect of exercise training in subjects with type 2 diabetes and the metabolic syndrome is dependent on exercise modalities and independent of weight loss. Nutr Metab Cardiovasc Dis 2010 20 608-617.

Donges CE, Duffield R & Drinkwater EJ: Effects of resistance or aerobic exercise training on interleukin-6, C-reactive protein, and body composition. Med Sci Sports Exerc 2010 42 304-313.

Hopps E, Canino B & Caimi G: Effects of exercise on inflammation markers in type 2 diabetic subjects. Acta Diabetol 2011 48 183-189.

Winnick JJ, Sherman WM, Habash DL, Stout MB, Failla ML, Belury MA & Schuster DP: Short-term aerobic exercise training in obese humans with type 2 diabetes mellitus improves whole-body insulin sensitivity through gains in peripheral, not hepatic insulin sensitivity. J Clin Endocrinol Metab 2008 93 771-778.

Chudyk A & Petrella RJ: Effects of exercise on cardiovascular risk factors in type 2 diabetes: a meta-analysis. Diabetes Care 2011 34 1228-1237.

Kodama S, Tanaka S, Saito K, Shu M, Sone Y, Onitake F, Suzuki E, Shimano H, Yamamoto S, Kondo K, Ohashi Y, Yamada N & Sone H: Effect of aerobic exercise training on serum levels of high-density lipoprotein cholesterol: a meta-analysis. Arch Intern Med 2007 167 999-1008.

Robins SJ, Collins D, Wittes JT, Papademetriou V, Deedwania PC, Schaefer EJ, McNamara JR, Kashyap ML, Hershman JM, Wexler LF & Rubins HB: Relation of gemfibrozil treatment and lipid levels with major coronary events: VA-HIT: a randomized controlled trial. Jama 2001 285 1585-1591.

Rubins HB, Robins SJ, Collins D, Fye CL, Anderson JW, Elam MB, Faas FH, Linares E, Schaefer EJ, Schectman G, Wilt TJ & Wittes J: Gemfibrozil for the secondary prevention of coronary heart disease in men with low levels of high-density lipoprotein cholesterol. Veterans Affairs High-Density Lipoprotein Cholesterol Intervention Trial Study Group. N Engl J Med 1999 341 410-418.

Madden KM, Lockhart C, Cuff D, Potter TF & Meneilly GS: Short-term aerobic exercise reduces arterial stiffness in older adults with type 2 diabetes, hypertension, and hypercholesterolemia. Diabetes Care 2009 32 1531-1535.

Irving BA, Davis CK, Brock DW, Weltman JY, Swift D, Barrett EJ, Gaesser GA & Weltman A: Effect of exercise training intensity on abdominal visceral fat and body composition. Med Sci Sports Exerc 2008 40 1863-1872.

Christiansen T, Paulsen SK, Bruun JM, Overgaard K, Ringgaard S, Pedersen SB, Positano V & Richelsen B: Comparable reduction of the visceral adipose tissue depot after a diet-induced weight loss with or without aerobic exercise in obese subjects: a 12-week randomized intervention study. Eur J Endocrinol 2009 160 759-767.

Nicklas BJ, Wang X, You T, Lyles MF, Demons J, Easter L, Berry MJ, Lenchik L & Carr JJ: Effect of exercise intensity on abdominal fat loss during calorie restriction in overweight and obese postmenopausal women: a randomized, controlled trial. Am J Clin Nutr 2009 89 1043-1052.

Baldi JC & Snowling N: Resistance training improves glycaemic control in obese type 2 diabetic men. Int J Sports Med 2003 24 419-423.

Ibanez J, Izquierdo M, Arguelles I, Forga L, Larrion JL, Garcia-Unciti M, Idoate F & Gorostiaga EM: Twice-weekly progressive resistance training decreases abdominal fat and improves insulin sensitivity in older men with type 2 diabetes. Diabetes Care 2005 28 662-667.

Misra A, Alappan NK, Vikram NK, Goel K, Gupta N, Mittal K, Bhatt S & Luthra K: Effect of supervised progressive resistance-exercise training protocol on insulin sensitivity, glycemia, lipids, and body composition in Asian Indians with type 2 diabetes. Diabetes Care 2008 31 1282-1287.

Winnick JJ, Gaillard T & Schuster DP: Resistance training differentially affects weight loss and glucose metabolism of White and African American patients with type 2 diabetes mellitus. Ethn Dis 2008 18 152-156.

Arora E, Shenoy S & Sandhu JS: Effects of resistance training on metabolic profile of adults with type 2 diabetes. Indian J Med Res 2009 129 515-519.

Castaneda C, Layne JE, Munoz-Orians L, Gordon PL, Walsmith J, Foldvari M, Roubenoff R, Tucker KL & Nelson ME: A randomized controlled trial of resistance exercise training to improve glycemic control in older adults with type 2 diabetes. Diabetes Care 2002 25 2335-2341.

Snowling NJ & Hopkins WG: Effects of different modes of exercise training on glucose control and risk factors for complications in type 2 diabetic patients: a meta-analysis. Diabetes Care 2006 29 2518-2527.

Thomas DE, Elliott EJ & Naughton GA: Exercise for type 2 diabetes mellitus. Cochrane Database Syst Rev 2006 CD002968.

Church TS, Blair SN, Cocreham S, Johannsen N, Johnson W, Kramer K, Mikus CR, Myers V, Nauta M, Rodarte RQ, Sparks L, Thompson A & Earnest CP: Effects of aerobic and resistance training on hemoglobin A1c levels in patients with type 2 diabetes: a randomized controlled trial. Jama 2010 304 2253-2262.

Boule NG, Kenny GP, Haddad E, Wells GA & Sigal RJ: Meta-analysis of the effect of structured exercise training on cardiorespiratory fitness in Type 2 diabetes mellitus. Diabetologia 2003 46 1071-1081.

Umpierre D, Ribeiro PA, Kramer CK, Leitao CB, Zucatti AT, Azevedo MJ, Gross JL, Ribeiro JP & Schaan BD: Physical activity advice only or structured exercise training and association with HbA1c levels in type 2 diabetes: a systematic review and meta-analysis. Jama 2011 305 1790-1799.

Negri C, Bacchi E, Morgante S, Soave D, Marques A, Menghini E, Muggeo M, Bonora E & Moghetti P: Supervised walking groups to increase physical activity in type 2 diabetic patients. Diabetes Care 2010 33 2333-2335.

Praet SF, van Rooij ES, Wijtvliet A, Boonman-de Winter LJ, Enneking T, Kuipers H, Stehouwer CD & van Loon LJ: Brisk walking compared with an individualised medical fitness programme for patients with type 2 diabetes: a randomised controlled trial. Diabetologia 2008 51 736-746.

Araiza P, Hewes H, Gashetewa C, Vella CA & Burge MR: Efficacy of a pedometer-based physical activity program on parameters of diabetes control in type 2 diabetes mellitus. Metabolism 2006 55 1382-1387.

Bjorgaas MR, Vik JT, Stolen T, Lydersen S & Grill V: Regular use of pedometer does not enhance beneficial outcomes in a physical activity intervention study in type 2 diabetes mellitus. Metabolism 2008 57 605-611.

Engel L & Lindner H: Impact of using a pedometer on time spent walking in older adults with type 2 diabetes. Diabetes Educ 2006 32 98-107.

Dunstan DW, Daly RM, Owen N, Jolley D, Vulikh E, Shaw J & Zimmet P: Home-based resistance training is not sufficient to maintain improved glycemic control following supervised training in older individuals with type 2 diabetes. Diabetes Care 2005 28 3-9.

Dunstan DW, Vulikh E, Owen N, Jolley D, Shaw J & Zimmet P: Community center-based resistance training for the maintenance of glycemic control in adults with type 2 diabetes. Diabetes Care 2006 29 2586-2591.

Taylor JD, Fletcher JP & Tiarks J: Impact of physical therapist-directed exercise counseling combined with fitness center-based exercise training on muscular strength and exercise capacity in people with type 2 diabetes: a randomized clinical trial. Phys Ther 2009 89 884-892.

Sigal RJ, Kenny GP, Wasserman DH & Castaneda-Sceppa C: Physical activity/exercise and type 2 diabetes. Diabetes Care 2004 27 2518-2539.

Waden J, Tikkanen H, Forsblom C, Fagerudd J, Pettersson-Fernholm K, Lakka T, Riska M & Groop PH: Leisure time physical activity is associated with poor glycemic control in type 1 diabetic women: the FinnDiane study. Diabetes Care 2005 28 777-782.

Selam JL, Casassus P, Bruzzo F, Leroy C & Slama G: Exercise is not associated with better diabetes control in type 1 and type 2 diabetic subjects. Acta Diabetol 1992 29 11-13.

Ligtenberg PC, Blans M, Hoekstra JB, van der Tweel I & Erkelens DW: No effect of long-term physical activity on the glycemic control in type 1 diabetes patients: a cross-sectional study. Neth J Med 1999 55 59-63.

Rejeski WJ, Ip EH, Bertoni AG, Bray GA, Evans G, Gregg EW & Zhang Q: Lifestyle change and mobility in obese adults with type 2 diabetes. N Engl J Med 2012 366 1209-1217.

Fritz T, Caidahl K, Osler M, Ostenson CG, Zierath JR & Wandell P: Effects of Nordic walking on health-related quality of life in overweight individuals with type 2 diabetes mellitus, impaired or normal glucose tolerance. Diabet Med 2011 28 1362-1372.

Levinger I, Selig S, Goodman C, Jerums G, Stewart A & Hare DL: Resistance training improves depressive symptoms in individuals at high risk for type 2 diabetes. J Strength Cond Res 2011 25 2328-2333.

Reid RD, Tulloch HE, Sigal RJ, Kenny GP, Fortier M, McDonnell L, Wells GA, Boule NG, Phillips P & Coyle D: Effects of aerobic exercise, resistance exercise or both, on patient-reported health status and well-being in type 2 diabetes mellitus: a randomised trial. Diabetologia 2011 53 632-640.

Madden KM, Lockhart C, Potter TF & Cuff D: Aerobic training restores arterial baroreflex sensitivity in older adults with type 2 diabetes, hypertension, and hypercholesterolemia. Clin J Sport Med 2010 20 312-317.

Madden KM, Lockhart CK, Potter TF, Cuff DJ & Meneilly GS: Short-term aerobic exercise reduces nitroglycerin-induced orthostatic intolerance in older adults with type 2 diabetes. J Cardiovasc Pharmacol 2011 57 666-671.

Song CH, Petrofsky JS, Lee SW, Lee KJ & Yim JE: Effects of an exercise program on balance and trunk proprioception in older adults with diabetic neuropathies. Diabetes Technol Ther 2011 13 803-811.

Ferrier KE, Nestel P, Taylor A, Drew BG & Kingwell BA: Diet but not aerobic exercise training reduces skeletal muscle TNF-alpha in overweight humans. Diabetologia 2004 47 630-637.

Sridhar B, Haleagrahara N, Bhat R, Kulur AB, Avabratha S & Adhikary P: Increase in the heart rate variability with deep breathing in diabetic patients after 12-month exercise training. Tohoku J Exp Med 2010 220 107-113.

Balducci S, Leonetti F, Di Mario U & Fallucca F: Is a long-term aerobic plus resistance training program feasible for and effective on metabolic profiles in type 2 diabetic patients? Diabetes Care 2004 27 841-842.

Christian JG, Bessesen DH, Byers TE, Christian KK, Goldstein MG & Bock BC: Clinic-based support to help overweight patients with type 2 diabetes increase physical activity and lose weight. Arch Intern Med 2008 168 141-146.

Di Loreto C, Fanelli C, Lucidi P, Murdolo G, De Cicco A, Parlanti N, Santeusanio F, Brunetti P & De Feo P: Validation of a counseling strategy to promote the adoption and the maintenance of physical activity by type 2 diabetic subjects. Diabetes Care 2003 26 404-408.

Hordern MD, Coombes JS, Cooney LM, Jeffriess L, Prins JB & Marwick TH: Effects of exercise intervention on myocardial function in type 2 diabetes. Heart 2009 95 1343-1349.

Jakicic JM, Jaramillo SA, Balasubramanyam A, Bancroft B, Curtis JM, Mathews A, Pereira M, Regensteiner JG & Ribisl PM: Effect of a lifestyle intervention on change in cardiorespiratory fitness in adults with type 2 diabetes: results from the Look AHEAD Study. Int J Obes (Lond) 2009 33 305-316.

Mayer-Davis EJ, D'Antonio AM, Smith SM, Kirkner G, Levin Martin S, Parra-Medina D & Schultz R: Pounds off with empowerment (POWER): a clinical trial of weight management strategies for black and white adults with diabetes who live in medically underserved rural communities. Am J Public Health 2004 94 1736-1742.

Trumbo P, Schlicker S, Yates AA & Poos M: Dietary reference intakes for energy, carbohydrate, fiber, fat, fatty acids, cholesterol, protein and amino acids. J Am Diet Assoc 2002 102 1621-1630.

Brand-Miller J, Hayne S, Petocz P & Colagiuri S: Low-glycemic index diets in the management of diabetes: a meta-analysis of randomized controlled trials. Diabetes Care 2003 26 2261-2267.

Erkkila AT, Lichtenstein AH, Mozaffarian D & Herrington DM: Fish intake is associated with a reduced progression of coronary artery atherosclerosis in postmenopausal women with coronary artery disease. Am J Clin Nutr 2004 80 626-632.

Kris-Etherton PM, Lichtenstein AH, Howard BV, Steinberg D & Witztum JL: Antioxidant vitamin supplements and cardiovascular disease. Circulation 2004 110 637-641.

Franz MJ, Bantle JP, Beebe CA, Brunzell JD, Chiasson JL, Garg A, Holzmeister LA, Hoogwerf B, Mayer-Davis E, Mooradian AD, Purnell JQ & Wheeler M: Evidence-based nutrition principles and recommendations for the treatment and prevention of diabetes and related complications. Diabetes Care 2002 25 148-198.





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