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Sudden unexplained death in the young – a genetic approach to non-structural cardiac defects

Rabah M Shawky
Published in : HAMDAN MEDICAL JOURNAL ; Vol 5, No 3 (2012)
DOI : 10.7707/hmj.v5i3.134


Sudden unexpected death syndrome (SUDS) is the abrupt, unexpected natural death of an apparently healthy individual. In many cases, the cause of SUDS in young people is a genetic heart disorder. These disorders may be structural abnormalities, which are responsible for a large majority of cases, or arrhythmogenic abnormalities, which account for only a small minority of cases (e.g. long QT syndrome, Burgada syndrome and catecholaminergic polymorphic ventricular tachycardia). Mutations in the genes responsible for these arrhythmogenic abnormalities as well as modes of inheritance and clinical presentations will be shortly discussed.

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