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This issue of the Hamdan Medical Journal is devoted to the pathogenesis and treatment of type 2 diabetes mellitus – a disease affecting more than 366 million people worldwide, and this number will continue to rise. Diabetes is associated with increased morbidity and premature mortality from vascular complications. Recent research indicates that diabetes is also a risk factor for cancer and liver disease. Apart from the individual suffering of the patients affected, diabetes imposes an enormous economic burden to society.
Thus, effective treatment and prevention are of the greatest importance in fighting this epidemic. In order to develop more potent and durable medications, we need to better understand the pathogenesis of this disease. In this issue you will find an extensive expert review on the complex pathogenesis of diabetes by Sabine Kahl and Michael Roden. We must not, however, forget that lifestyle intervention by diet and exercise is the first and most important step for diabetes treatment. This topic is covered by Subash Sivaraman and Michael Weickert. Unfortunately, most patients do not reach the glycaemic target by lifestyle modification only and pharmacotherapy has to be introduced. I will try to provide an overview of current and future pharmacotherapy, which is becoming more and more complex. Felix Langer and Gerhard Prager, finally, will review bariatric surgery, which has proven very effective in treating severely obese patients.
I hope we meet your expectations and that some of the concepts outlined in this journal will eventually help you with the treatment of your diabetic patients.