Hamdan Medical Journal (previously the Journal of Medical Sciences)

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Th-1, Th-2 cells and beyond

M L Lukic
Published in : Journal of Medical Sciences ; Vol 1, No 1 (2008)
DOI : 10.2174/1996327000801010005


The proliferation and differentiation of naïve CD4+ T helper (Th) cells after antigenic stimulation leads to functionally distinct subsets with different roles in immune response: Th-1 and Th-2 cells. Th- 1 cells produce large quantities of Interferon γ (INF-γ) inducing cell mediated immune responses against intracellular pathogens whereas Th-2 cells produce Interleukin (IL) 4, IL-5 and IL-13 which mediate humoral immunity eliminating extracellular pathogens and parasites.

Cite this article (Note that the Hamdan Medical Journal was previously called the Journal of Medical Sciences):
Lukik, ML. Th-1, Th-2 cells and beyond. Journal of Medical Sciences, 2008; 1(1): 5-7. DOI: http://dx.doi.org/10.2174/1996327000801010005

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