Table of Contents  

Role of adiponectin in acute biliary pancreatitis – a prospective case–control study

Samer Sawalhi, Hamdi Al-Maramhy, Salman Al-Jubori, Abdelrahman l-Abdelrahman, Salah Eldin Geib Allah
Published in : HAMDAN MEDICAL JOURNAL ; Vol 7, No 1 (2014)
DOI : 10.7707/hmj.v7i1.296

Abstract


The prevalence of acute pancreatitis (AP) is increasing and is paralleled by an increased prevalence of obesity. High levels of adipocytokines, including adiponectin, can indicate a large amount of visceral fat surrounding the pancreas. Our aim is to study the ability of serum adiponectin to predict the clinical severity of acute biliary pancreatitis and its potential use as a marker of body mass index (BMI). Data were collected from 102 patients in this prospective study who were diagnosed with initial acute biliary pancreatitis between January 2010 and April 2013. Waist circumference and BMI were measured and serum adiponectin levels were analysed at the time of admission using enzyme-linked immunosorbent assay (ELISA). In addition, plasma samples of adiponectin were taken from an age-, sex- and BMI-matched control group. Our results showed that BMI was significantly correlated with pancreatitis severity (P=0.007) and there was a negative relationship between BMI and adiponectin levels with a Pearson correlation coefficient of <0.45 (P=0.001). Serum adiponectin did not correlate with weight or waist circumference and, furthermore, serum adiponectin was significantly lower in patients with AP than in the control subjects (P<0.0001). Obesity is a risk factor for developing severe AP and we demonstrate that measuring the serum adiponectin level can be used as a new marker for BMI at the time of hospital admission; however, adiponectin failed to serve as predictive marker of clinical severity.


View article in  :   PDF     HTML    



Add comment 





Home  Editorial Board  Search  Current Issue  Archive Issues  Announcements  Aims & Scope  About the Journal  How to Submit  Contact Us
Find out how to become a part of the HMJ  |   CLICK HERE >>
© Copyright 2012 - 2013 HMJ - HAMDAN Medical Journal. All Rights Reserved         Website Developed By Cedar Solutions INDIA