Hamdan Medical Journal (previously the Journal of Medical Sciences)

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From TNF and IL-1 to IL-17: The Destructive Cytokine Network in Rheumatoid Arthritis

Pierre Miossec
Published in : Journal of Medical Sciences ; Vol 1, No 1 (2008)
DOI : 10.2174/1996327000801010017

Abstract


Although its precise etiology remains unknown, examination of the inflammatory synovium in rheumatoid arthritis (RA) shows complex interactions involving cell contacts and soluble mediators, namely cytokines. Over the years and starting in 1983, the work of Miossec and colleagues has focused on the role of these interactions in the unbalanced equilibrium in favor of inflammation and destruction with emphasis on the regulatory effect of T cell subsets and their derived cytokines to dissect the communication network inside the synovium.


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References


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