Hamdan Medical Journal (previously the Journal of Medical Sciences)

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Cytokines in Health and Disease

Richard Flavell
Published in : Journal of Medical Sciences ; Vol 1, No 1 (2008)
DOI : 10.2174/1996327000801010026


Cytokines play a critical role in mediating inflammation and immune response. First, cytokines play a critical role in the recognition of pathogens through the innate immune response. Proinflammatory cytokines such as TNF-α play a critical role in enabling cells of the immune system to gain access to the site of infection and mediate the destruction of pathogens. Following initial pathogen recognition, the adaptive immune system is potentiated by cytokines produced by the innate immune system in conjunction with the recognition of pathogens through pattern recognition receptors, such as Toll-like receptors. In the adaptive immune response T cells differentiate into so-called effector cells which mediate immune protection from pathogens.


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