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Rotarix™ from early discovery to widespread use
Prior to the introduction of rotavirus vaccines, rotavirus was the predominant cause of childhood gastroenteritis worldwide. In this review, we discuss the rationale for developing a rotavirus vaccine and, more specifically, the development of a live attenuated single-strain vaccine. Early trials are described as well as the later trials in the developing world. The early impact of rotavirus vaccines has been even better than expected but challenges remain in making the vaccines available in areas where the burden of disease is greatest.