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Discovery of innovative small-molecule therapeutics

Magid Abou-Gharbia
Published in : HAMDAN MEDICAL JOURNAL ; Vol 7, No 4 (2014): Volume 7 Supplement 1
DOI : 10.7707/hmj.393


Small molecules, including natural products, have dramatically expanded the impact of basic biomedical research, creating opportunities for remarkable discoveries and the identification of novel therapeutics. They are invaluable tools that facilitate the study of biological processes and validation of disease targets. Breakthrough discoveries produced through the examination of biologically active small molecules include innovative treatment of cancer, immune-mediated inflammatory diseases, neuropsychiatric disorders, neurodegenerative conditions and many others. This presentation will highlight three programmes that led to the discovery of first-in-class therapeutics. These key drugs alleviate the suffering of millions of patients around the globe.


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