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A case of diffuse large B-cell lymphoma presenting in a patient with a family history of other types of cancers

Mohamed Alaqqad, Packirisamy Kannan, Leela Ram, Hytham Elshamsy, Tarek Refat Elhefni, Ishfaq A Khan, Ishfaq A Khan
Published in : HAMDAN MEDICAL JOURNAL ; Vol 8, No 4 (2015)
DOI : 10.7707/hmj.421


A 31-year-old man presented to an outpatient clinic with a painless lump in the groin, which increased in size over the course of 6 months, without other significant manifestations. The patient had a family history of different malignancies. A diagnostic approach was used to investigate the lump in the patient’s groin. It was concluded that the lump was a diffuse large B-cell lymphoma (DLBCL): an aggressive or fast-growing lymphoma arising in lymph nodes or outside the lymphatic system. DLBCL is the most common form of non-Hodgkin’s lymphoma (NHL), but there are several subtypes, which may affect prognosis and treatment. The first symptom of DLBCL is a painless lump, and this followed by an occasionally painful yet rapidly growing swelling in the neck, armpit or groin caused by enlargement of lymph nodes. Other symptoms include night sweats, unexplained fevers and weight loss, all of which were absent in this case. Most DLBCL patients are adults, although this type of lymphoma is sometimes is observed in children.

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