Hamdan Medical Journal (previously the Journal of Medical Sciences)
|Table of Contents|
Tissue Specific Stem Cells - The Lesson from Hematopoietic Stem Cell Transplantation
In the clinical application of tissue-specific stem cells, the lessons from hematopoietic stem cell transplantation are first, the importance of selective clonal culture assays to characterize and monitor stem cells, and second, the identification, mass production and use of tissue-specific growth regulatory factors to promote the growth of transplanted stem cells. This review will discuss some of the questions at issue in the currently popular subject of stem cells. In particular, the discussion will try to set the questions in the context of likely clinical applications. Are such applications really feasible and what information is still missing that is likely to be needed for successful clinical applications? The review will use hematopoietic stem cells as a useful case study where, at least some of the lessons emerging are likely to be relevant for other tissue-specific stem cells.
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