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Warfarin- and aspirin-associated fetal intracranial haemorrhage
Warfarin can cross the placental barrier and can cause perinatal intraventricular haemorrhage irrespective of maternal INR (international normalized ratio) level. The prevalence of perinatal intraventricular haemorrhage related to maternal warfarin is 4.6– 5.1% in autopsy studies of stillbirth. Previously reported cases of warfarin-associated fetal intracranial haemorrhage in pregnant women with a mechanical heart valve are shown in Table 1. This is a case report of a neonate who experienced perinatal intraventricular haemorrhage related to maternal warfarin.