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Alolama: The antisecretory factor-16

The antisecretory factor-16 (AF-16 or AS-factor) is the synthetic 16 amino acid peptide part of the antisecretory factor (AF) protein. AF is a protein with a molecular weight of 41 kDa. It was originally isolated from pig pituitary gland. AF counteracts experimentally induced diarrhoea and inflammatory reactions in the small intestine. Professor Stefan Lange et al. were searching for the antibody that gives people who survive cholera at least 1 year’s immunity. In their search they found AS-factor, and in 1995 managed to isolate AF from piglet brain. AF can be found in almost all living cells. It is normally inactive but can be activated by bacterial toxins or by oral intake of specially processed cereals. Researchers found that AF-16 affects lipid rafts and caveolae via flotillin-1. AF-16 either exerts no or only minor effects under normal conditions. In contrast, AF-16 monitors and normalizes abnormal functions in lipid rafts and caveolae. It restores actin filaments and flotillin oligomers, thereby influencing ion channel function. In our research we observed that AF-16 reduced the intracranial pressure caused by trauma or inflammation. We also showed that AF-16 decreased tumour pressure and that high AF concentration in serum was associated with a 100% survival rate after herpes encephalitis in rats (where otherwise the mortality rate was 100%).




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