Hamdan Medical Journal (previously the Journal of Medical Sciences)

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Studies of Immune Mechanisms of Diabetes and Treatment with Isolated Pancreatic Islets

Clyde F Barker, Ali Naji
Published in : Journal of Medical Sciences ; Vol 3, No 1 (2010)
DOI : 10.2174/1996327001003010040

Abstract


Reviewed here are studies in animal models of type I diabetes that have led to better understanding of the disease and progress to its cure by of pancreatic islet transplantation and/or manipu-lations of the immune system. These studies include: 1) the first complete and permanent cure of chemi-cally induced diabetes in rodents; 2) demons-tration of autoimmune recurrence of diabetes in islet recipients; 3) induction of intrathymic tolerance to islets; 4) prevention of autoimmune diabetes by thymic manipulation; and 5) demonstration of the importance of B lymphocytes in autoimmune diabetes and islet rejection. These experimental studies over the last four decades are the basis of a successful ongoing human islet transplant program.

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References


Ballilnger WF, Lacy PE. Transplantation of Intact Pancreatic Islets in Rats. Surgery 1972; 72: 175-86.

Reckard CR, Barker CF. Transplantation of Isolated Pancreatic Islets across Strong and Weak Histocompatibility Barriers. Transplant Proc 1973; 5:761-3.

Reckard CR, Ziegler MM, BarkerCF. Physiological and Immunological Consequences of Transplanting Pancreatic Islets. Surgery 1973; 74:91-9

Naji A, Silvers WK, Dafoe DC, Barker CF. Successful Islet Transplantation in Spontaneous Diabetes.Surgery 1979; 86: 218-26.

Naji A, Silvers WK, Bellgrau D, BarkerCF.Spontaneous Diabetes in Rats: Destruction of Islets is prevented by Immunological Tolerance. Science 1982; 213: 1390-2.

Sutherland DE, Sibley R, Xu XZ, Michael A, Srikanta AM, Taub F, et al. Twin to Twin Pancreas Transplantation Reversal and Reanactment of the Patholgensis of Type I Diabetes. Trans Assoc Am Physicians 1984; 97: 80-7.

Posselt AM, Barker CF, Friedman AL, Naji A.Prevention of Autoimmune Diabetes in the BB Rat by Intrathymic Islet Transplantation at Birth.Science1992; 256: 1321-4.

Posselt AM, Naji A, Roark JH, Markmann,JF, Barker CF. Intrathymic Islet Transplantation in the Spontaneously Diabetic BB Rat. Ann Surg 1991;214: 363-73.

Posselt, AM, Barker CF, Tomaszewski JE, Markmann JF, Choti MA, Naji A. Induction of Donor Specific Unresponsiveness by Intrathymic Islet Transplantation. Science 1990; 249: 1293-5.

Noorchashm H, Noorchashm N, Kern J, Rostami SY,Barker CF, Naji A. B-Cells are Required for Initiation of Insulitis and Sialitis in Nonobese Diabetic Mice. Diabetes 1997; 46: 941-6.

Noorchashm H, Moore DJ, Noto LE, Noorchashm N, Reed AJ, Reed AL, et al. Impaired CD4 T cell activation due to reliance upon B cell-mediated costimulation in nonobese diabetic (NOD) mice. JImmunol 2000; 165: 4685-96.

Noorchashm H, Lieu YK, Noorchashm N, Rostami SY, Greeley SA, Schlachterman A, et al. I-Ag7-mediated antigen presentation by B lymphocytes is critical in overcoming a checkpoint in T cell tolerance to islet beta cells of nonobese diabetic mice. J Immunol 1999; 163: 743-50.

Quinn WJ 3rd, Noorchashm N, Crowley JE, Reed AJ, Noorchashm H, Naji A, et al. Cutting Edge:Impaired Transitional B Cell Production and Selection in the Nonobese Diabetic Mouse. J Immunol 2006; 176: 7159-64.

Zekavat G, Rostami SY, Badkerhanian A, Parsons RF, Koeberlein B, Yu M, et al. In vivo BLyS/BAFF neutralization ameliorates islet-directed autoimmunity in nonobese diabetic mice. J Immunol 2008; 181: 8133-44.

Liu C, Noorchashm H, Sutter JA, Naji M, Prak EL,Boyer J, et al. B lymphocyte-directed immunotherapy promotes long-term islet allograft survival in nonhuman primates. Nat Med 2007; 13:1295-8.

Markmann JF, Deng S, Huang X, Desai NM,Velidedeoglu EH, Lui C, et al. Insulin Independence Following Isolated Islet Transplantation and Single Islet Infusions. Ann Surg 2003; 237: 741-50.

Frank A, Deng S, Huang X, Velidedeoglu E, Bae YS,Liu C, et al. Transplantation for type I diabetes:comparison of vascularized whole-organ pancreas with isolated pancreatic islets. Ann Surg 2004; 240: 631-43.





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