Hamdan Medical Journal (previously the Journal of Medical Sciences)

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Studies of Immune Mechanisms of Diabetes and Treatment with Isolated Pancreatic Islets

Clyde F Barker, Ali Naji
Published in : Journal of Medical Sciences ; Vol 3, No 1 (2010)
DOI : 10.2174/1996327001003010040


Reviewed here are studies in animal models of type I diabetes that have led to better understanding of the disease and progress to its cure by of pancreatic islet transplantation and/or manipu-lations of the immune system. These studies include: 1) the first complete and permanent cure of chemi-cally induced diabetes in rodents; 2) demons-tration of autoimmune recurrence of diabetes in islet recipients; 3) induction of intrathymic tolerance to islets; 4) prevention of autoimmune diabetes by thymic manipulation; and 5) demonstration of the importance of B lymphocytes in autoimmune diabetes and islet rejection. These experimental studies over the last four decades are the basis of a successful ongoing human islet transplant program.

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