Hamdan Medical Journal (previously the Journal of Medical Sciences)

Table of Contents  

Discovery of Ghrelin and Its Physiological Function

Masayasu Kojima
Published in : Journal of Medical Sciences ; Vol 3, No 2 (2010)
DOI : 10.2174/1996327001003020092


The endogenous ligand for growth-hormone secretagogue receptor (GHS-R) was discovered in 1999 from stomach and named it "ghrelin," after a word root ("ghre") in Proto-Indo-European languages meaning "grow", since ghrelin stimulates growth hormone (GH) release from pituitary. In addition, ghrelin stimulates appetite and increases food intake by acting on the hypothalamic arcuate nucleus, a region known to control food intake. Thus, ghrelin plays important roles for maintaining growth hormone release and energy homeostasis in vertebrates. The diverse functions of ghrelin raise the possibility of its clinical application for GH deficiency, eating disorder, gastrointestinal disease, cardiovascular disease, osteoporosis and aging, etc.


Ghrelin; acyl-modification; stomach; growth hormone releasing

View article in  :   PDF    


Kojima M, Hosoda H, Date Y, Nakazato M, Matsuo H, Kangawa K. Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature 1999; 402: 656-60.

Kojima M, Kangawa K. Ghrelin: structure and function. Physiol Rev 2005; 85: 495-522.

Nishi Y, Hiejima H, Hosoda H, Kaiya H, Mori K, Fukue Y, et al. Ingested medium-chain fatty acids are directly utilized for the acyl modification of ghrelin. Endocrinology 2005; 146: 2255-64.

Date Y, Kojima M, Hosoda H, Sawaguchi A, Mondal MS, Suganuma T, et al. Ghrelin, a novel growth hormonereleasing acylated peptide, is synthesized in a distinct endocrine cell type in the gastrointestinal tracts of rats and humans. Endocrinology 2000; 141: 4255-61.

Date Y, Nakazato M, Hashiguchi S, Dezaki K, Mondal MS, Hosoda H, et al. Ghrelin is present in pancreatic alphacells of humans and rats and stimulates insulin secretion. Diabetes 2002; 51: 124-9.

Nakazato M, Murakami N, Date Y, Kojima M, Matsuo H, Kangawa K, et al. A role for ghrelin in the central regulation of feeding. Nature 2001; 409: 194-8.

Add comment 

Home  Editorial Board  Search  Current Issue  Archive Issues  Announcements  Aims & Scope  About the Journal  How to Submit  Contact Us
Find out how to become a part of the HMJ  |   CLICK HERE >>
© Copyright 2012 - 2013 HMJ - HAMDAN Medical Journal. All Rights Reserved         Website Developed By Cedar Solutions INDIA