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Rosen: Overview of management of hepatobiliary malignancies

Primary liver malignancies can originate either from hepatocytes or from bile duct cells and can manifest as hepatocellular carcinomas or cholangiocarcinomas. These cancers combined are the second most common cause of cancer-related death, and their incidence is increasing. Hepatocellular carcinoma, in particular, occurs worldwide and is usually a consequence of hepatitis and liver cirrhosis whether due to infection or alcohol induced.

This issue of Hamdan Medical Journal offers readers an insight into the improvements in the knowledge and understanding of hepatobiliary malignancies that have been achieved in recent decades. It will focus on diagnosis and modern staging, showing molecular abnormalities that have been identified by new laboratory technologies and the possibility of a more accurate classification of the disease by imaging and patient characterization.

Furthermore, two excellent state-of-the-art reviews provide an overview of multimodal treatment options. These range from local tumour control using interventional approaches (tumour ablation, chemoembolization) to radical surgery (liver resection or even liver transplantation, if indicated), which can now significantly improve outcomes in patients with hepatobiliary cancer.

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