Hamdan Medical Journal (previously the Journal of Medical Sciences)

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Major Accomplishments of Four Decades of Research on the Thyroid Gland

P Reed Larsen
Published in : Journal of Medical Sciences ; Vol 3, No 2 (2010)
DOI : 10.2174/1996327001003020096


Thyroid hormones, thyroxine (T4) and 3,5,3' triiodothyronine (T3), are present in all members of the vertebrate kingdom. The active hormone, T3, is required for such varied processes as metamorphosis in amphibians, normal growth and brain development in infants and children, and the maintenance of normal metabolic rate in adults. This invited review summarizes the contributions of Dr. Larsen’s laboratory to this field, ranging from those in public health to those defining the molecular mechanisms required for the monodeiodination of T4 to form the active hormone, T3.


Deiodinase; hypothyroidism; selenocysteine; thyroxine

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