Hamdan Medical Journal (previously the Journal of Medical Sciences)
|Table of Contents|
Major Accomplishments of Four Decades of Research on the Thyroid Gland
Larsen PR, Broskin K. Thyroxine (T4) immunoassay using a filter paper blood samples for screening of neonates for hypothyroidism. Pediatr Res 1975; 9: 604-9.
Larsen PR, Merker A, Parlow AF. Immunoassay of human TSH using dried blood samples. J Clin Endocrinol Metab 1976; 42: 987-90.
LaFranchi SH, Murphey WH, Foley TP Jr, Larsen PR, Buist NR. Neonatal hypothyroidism detected by the Northwest Regional Screening Program. Pediatrics 1979; 63: 180-91.
Mitchell ML, Larsen PR, Levy HL, Bennett AJ, Madoff MA. Screening for congenital hypothyroidism. Results in the newborn population of New England. JAMA 1978; 239: 2348-51.
Fisher DA, Dussault JH, Foley TP Jr, Klein AH, LaFranchi S, Larsen PR, et al. Screening for congenital hypothyroidism: results of screening one million North American infants. J Pediatr 1979; 94: 700-5.
Abrams GM, Larsen PR. Triiodothyronine and thyroxine in the serum and thyroid glands of iodine-deficient rats. J Clin Invest 1973; 52: 2522-2531.
Riesco G, Taurog A, Larsen R, Krulich L. Acute and chronic responses to iodine deficiency in rats. Endocrinology 1977; 100: 303-13.
Silva JE, Larsen PR. Pituitary nuclear 3,5,3'- triiodothyronine and thyrotropin secretion: an explanation for the effect of thyroxine. Science 1977; 198: 617-20.
Leonard JL, Kaplan MM, Visser TJ, Silva JE, Larsen PR. Cerebral cortex responds rapidly to thyroid hormones. Science 1981; 214: 571-3.
Visser TJ, Leonard JL, Kaplan MM, Larsen PR. Kinetic evidence suggesting two mechanisms for iodothyronine 5'- deiodination in rat cerebral cortex. Proc Natl Acad Sci USA 1982; 79: 5080-4.
Larsen PR. Thyroid-pituitary interaction: feedback regulation of thyrotropin secretion by thyroid hormones. N Engl J Med 1982; 306: 23-32.
Silva JE, Leonard JL, Crantz FR, Larsen PR. Evidence for two tissue specific pathways for in vivo thyroxine 5'deiodination in the rat. J Clin Invest 1982; 69: 1176-84.
Peeters R, Fekete C, Goncalves C, Legradi G, Tu HM, Harney JW, et al. Regional physiological adaptation of the central nervous system deiodinases to iodine deficiency. Am J Physiol Endocrinol Metab 2001; 281: E54-61.
Silva JE, Larsen PR. Contributions of plasma triiodothyronine and local thyroxine monodeiodination to triiodothyronine to nuclear triiodothyronine receptor saturation in pituitary, liver, and kidney of hypothyroid rats. Further evidence relating saturation of pituitary nuclear triiodothyronine receptors and the acute inhibition of thyroid- stimulating hormone release. J Clin Invest 1978; 61: 1247-59.
Berry MJ, Banu L, Larsen PR. Type I iodothyronine deiodinase is a selenocysteine-containing enzyme. Nature 1991; 349: 438-40.
Berry MJ, Banu L, Chen YY, Mandel SJ, Kieffer JD, Harney JW, et al. Recognition of UGA as a selenocysteine codon in type I deiodinase requires sequences in the 3' untranslated region. Nature 1991; 353: 273-6.
Berry MJ, Banu L, Harney JW, Larsen PR. Functional characterization of the eukaryotic SECIS elements which direct selenocysteine insertion at UGA codons. EMBO J 1993; 12: 3315-22.
Kryukov GV, Castellano S, Novoselov SV, Lobanov AV, Zehtab O, Guigo R, et al. Characterization of mammalian selenoproteomes. Science 2003; 300: 1439-43.
Bartha T, Kim SW, Salvatore D, Gereben B, Tu HM, Harney JW, et al. Characterization of the 5'-flanking and 5'-untranslated regions of the cyclic adenosine 3',5'- monophosphate-responsive human type 2 iodothyronine deiodinase gene. Endocrinology 2000; 141: 229-37.
Silva JE, Larsen PR. Hormonal regulation of iodothyronine 5'-deiodinase in rat brown adipose tissue. Am J Physiol 1986; 251: E639-E643.
Silva JE, Larsen PR. Insulin, glucose, and glucagon are potential modulators of thyroid hormone action through brown adipose tissue 5'-deiodinase in rats. In: Medeiros- Neto G and Gaitan E, Eds., Frontiers in Thyroidology. New York, Plenam 1986: 767-71.
Barge RM, Mills I, Silva JE, Larsen PR. Phorbol esters, protein kinase C, and thyroxine 5'-deiodinase in brown adipocytes. Am J Physiol 1988; 254: E323-7.
Mills I, Raasmaja A, Moolten N, Lemack G, Silva JE, Larsen PR. Effect of thyroid status on catecholamine stimulation of thyroxine 5'- deiodinase in brown adipocytes. Am J Physiol 1989; 256: E74-79.
Steinsapir J, Harney J, Larsen PR. Type 2 iodothyronine deiodinase in rat pituitary tumor cells is inactivated in proteasomes. J Clin Invest 1998; 102: 1895-99.
Steinsapir J, Bianco AC, Buettner C, Harney J, Larsen PR. Substrate-induced down-regulation of human type 2 deiodinase (hD2) is mediated through proteasomal degradation and requires interaction with the enzyme's active center. Endocrinology 2000; 141: 1127-35.
Salvatore D, Bartha T, Harney JW, Larsen PR. Molecular biological and biochemical characterization of the human type 2 selenodeiodinase. Endocrinology 1996; 137: 3308-15.
Salvatore D, Tu H, Harney JW, Larsen PR. Type 2 iodothyronine deiodinase is highly expressed in human thyroid. J Clin Invest 1996; 98: 962-8.
Gouveia CH, Christoffolete MA, Zaitune CR, Dora JM, Harney JW, Maia AL, et al. Type 2 iodothyronineselenodeiodinase is expressed throughout the mouse skeleton and in the MC3T3-E1 mouse osteoblastic cell line during differentiation. Endocrinology 2005; 146: 195-200.
Huang SA, Tu HM, Harney JW, Venihaki M, Butte AJ, Kozakewich HP, et al. Severe hypothyroidism caused by type 3 iodothyronine deiodinase in infantile hemangiomas. N Engl J Med 2000; 343: 185-9.
Huang SA, Fish SA, Dorfman DM, Salvatore D, Kozakewich HP, Mandel SJ, et al. A 21-year-old woman with consumptive hypothyroidism due to a vascular tumor expressing type 3 iodothyronine deiodinase. J Clin Endocrinol and Metabolism 2002; 87: 4457-61.