Hamdan Medical Journal (previously the Journal of Medical Sciences)

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Cinnamaldehyde Induces Behavioral and Biochemical Changes in the Male Albino Wistar Rat

Sivakumar J. T Gowder, Devaraj Halagowder
Published in : Journal of Medical Sciences ; Vol 3, No 2 (2010)
DOI : 10.2174/1996327001003020101


Cinnamaldehyde (CNMA) is a widely consumed food flavoring. In addition, it is also used as an antiseptic and an antiallergic drug and as a tonic in traditional Chinese medicines. Certain behavioral parameters were carried out in this study to evaluate the effect of CNMA on rats. Rats were given CNMA orally by gavage at the dose levels of 2.14, 6.96, 22.62 and 73.5mg/kg body weight/day for the period of 10, 30 or 90 days. Only the group of rats treated with CNMA at the dose of 73.5 mg/kg body weight/day for 90 days showed significant changes in the olfactory discrimination, auditory startle response and negative geotaxis behavior. No treatment related impairment of cliff avoidance behavior was noted. Thus, CNMA has an effect on the neuromuscular system. This is evident from changes in acetyl cholinesterase (AChE) and creatine kinase (CK) activities in the serum of these rats. Further examination of non-enzymatic and enzymatic antioxidants and also thiobarbituric acid reactive substances (TBARS) in the serum showed CNMA induced oxidative stress that resulted in the behavioral changes of these rats. From this study, we can conclude that the oxidative stress induced by CNMA has an effect on rat behavior and its effect is time and dose dependent.


Behavior; cinnamaldehyde; food flavor; rat; serum enzymes

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