Table of Contents  

Haemophagocytic lymphohistiocytosis and the challenge of early diagnosis: a case report

Hoda Mohamed Hammoda, Mahmoud Mohamed Marashi, Hesham Abdalla Mohamed Abdalla, Mahmod EL Shahat Awad Makhlof, Manal Sayed Rezzek
Published in : HAMDAN MEDICAL JOURNAL ; Future Issues
DOI : 10.7707/hmj.775


Hemophagocytic lymphohistiocytosis (HLH) is an uncommon, life-threatening hyperinflammatory Syndrome with massive tissue destruction secondary to hypercytokinemia and excessive activation of lymphocytes and macrophages due to abnormal, ineffective energizing of the immune system. A high index of suspicion is necessary for early diagnosis. We report a case of Hemophagocytic Lymphohistiocytosis in a 66-year-old lady presented with fever, pancytopenia, and hepatosplenomegaly.

View article in  :   PDF     HTML    


Henter J I, Horne AC, Arico M, et al. HLH-2004: Diagnostic and Therapeutic Guidelines for Hemophagocytic Lymphohistiocytosis. Pediatric Blood Cancer 2007; 48:124–131.

Henter J-I, So¨der O,O¨ stA ° , et al. Incidence and clinical features of familial hemophagocytic lymphohistiocytosis in Sweden. Acta

Paediatr Scand 1991;80:428–435.

Farquhar JW, Claireaux AE. Familial haemophagocytic reticulosis. Arch Dis Child. 1952;27:519-525.

Otrock ZK and Eby CS. Clinical characteristics, prognostic factors, and outcomes of adult patients with hemophagocytic lymphohistiocytosis. Am J Hematol.


Sheila Weitzman. Approach to Hemophagocytic Syndromes. American Society of Hematology 2011;178-183.

Fisman DN. Hemophagocytic Syndromes and Infection. Emerging infectious diseases 2000;6:601-608.

Jordan MB, Allen CE, Weitzman S, et al How I treat hemophagocytic lymphohistiocytosis. The American Society of Hematology 2011;118: 4041- 4052.

Add comment 

Home  Editorial Board  Search  Current Issue  Archive Issues  Announcements  Aims & Scope  About the Journal  How to Submit  Contact Us
Find out how to become a part of the HMJ  |   CLICK HERE >>
© Copyright 2012 - 2013 HMJ - HAMDAN Medical Journal. All Rights Reserved         Website Developed By Cedar Solutions INDIA