Hamdan Medical Journal (previously the Journal of Medical Sciences)

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Natural History to Molecular Pathogenesis to Preventive Trials

George S Eisenbarth
Published in : Journal of Medical Sciences ; Vol 3, No 3 (2010)
DOI : 10.2174/1996327001003030136


Humans, mice and rats are susceptible to autoimmune diabetes we believe due to common molecular sequences of the trimolecular complex targeting of insulin, when tolerance mechanisms fail. The disease is now predictable in man, preventable in animal models, and recent trials indicate the potential for preventive therapy in man.


Autoimmunity; HLA; NOD mouse; Type 1A diabetes; trimolecular

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