Hamdan Medical Journal (previously the Journal of Medical Sciences)

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Clinical Applications of Amphibian Antimicrobial Peptides

J. Michael Conlon, Agnes Sonnevend
Published in : Journal of Medical Sciences ; Vol 4, No 2 (2011)
DOI : 10.2174/1996327001104020062

Abstract


Frog skin constitutes a rich source of peptides with broad spectrum antimicrobial activity against strains of antibiotic-resistant bacteria and fungi and several hundred such peptides from diverse species have been described. However, their therapeutic potential remains to be realized and no anti-infective peptide based upon their structures has yet been adopted in clinical practice. This review assesses potential clinical applications of nine antimicrobial peptides isolated from frog skin (alyteserin-1c, ascaphin-8, brevinin-1BYa, brevinin-2PRa, brevinin-2-related peptide, brevinin-2- related peptide-ERa, kassinatuerin-1, pseudin-2, and temporin-DRa). The multidrug-resistant microorganisms targeted include the Gram-negative bacteria Acinetobacter baumannii, Escherichia coli, Klebsiella pneumonia, and Pseudomonas aeruginosa, the Gram-positive bacterium Staphylococcus aureus, and the opportunistic yeast pathogens Candida spp. Although the naturally occurring peptides show varying degrees of cytotoxicity towards mammalian cells such as erythrocytes, analogs have been developed that retain high antimicrobial potency but are nonhemolytic. Treatment and prevention of acne and periodontal disease are identified as areas in which frog skin antimicrobial peptides might find future applications.

Keywords


Frog skin; antimicrobial peptide; antibiotic-resistant bacteria

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