Profile of Salim Mohd. Abdulrazzaq Bastaki

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Curriculum Vitae

Name:                                     Salim Mohd. Abdulrazzaq Bastaki

Date of Birth:                         29-08-1949

Place of Birth:                       Dubai

Nationality:                            UAE

Social Status:                         Married with two sons.

Address, Telephone, and fax:

Department of Pharmacology
Faculty of Medicine and Health Sciences
United Arab EmiratesUniversity,
P.O. Box 17666, Al Ain, UAE.
Tel: (971). 3.7137520 (off)
Fax: (971). 3.7672033
E-mail: sbastaki@uaeu.ac.ae

Education:                            

St. Aloysius High School, Bombay (1956-1967)

Diploma in Pharmacy (D. Pharm.), Govt. College of Pharmacy, Bombay, India, 1969.

Bachelor in Pharmacy (B. Pharm.), University of Karnataka, Bangalore, India, 1977.

Ph D. in Pharmacology and Physiology, University of Strathclyde, Glasgow, Scotland, UK, 1985.

Postdoctoral Fellowship, University of Strathclyde, Glasgow, March 1985 to October 1985.

Membership of ScientificSocieties: Physiological Society for Asia and the Pacific (FAOPS)

Society for Experimental Biology and Medicine (SEBM)

American Gastroenterology Society

European Teratology Society

Languages:                            English (Read, write and speak fluently)
Arabic (Read and speak local dialect)
French (read only)    

                          
Hobbies:                                 Astronomy, Natural History, Travel, Sports.


General Knowledge-Won first prize at General knowledge competition at the University of Bangalore (twice)

Past Position                          Assistant Professor of Pharmacology, FMHS (1990-2002)
Past Position:                         Associate Professor of Pharmacology, FMHS (2002-to present)
Present Position:                    Professor (2010-till date--) and chair (September 1014)

Previous Work Experience:

Chief Pharmacist in a retail Pharmacy, Dubai.1969-1973.

Chief Pharmacist in Al Khan Clinic and Head of    Central Drug Store, Sharjah, M.O.H., UAE. 1978- 1980.

Head of Drug Registration Department for the  Northern Emirates in Dubai (MOH).1985-1990.

Teaching experience: I Taught Respiratory, Central nervous system, Gastrointestinal tract, Behavior Science Module and Pathobiology Modules) to Undergraduate students and toxicology to Postgraduate students. I also taught Iatrogenic disorders of the nervous system during the year 92-93. I also taught haematology module up to the year 2004. I also taught Pharmacology to Higher College of Technology Students. At present I teach the Premed 4 and , Preclinical-1  (OSC-1), and Preclinical-2 (OSC-2).

Research interest:

  1. Gastroenterology: Gastrointestinal diseases have increased in recent years. Work stress, alcohol, non-steroidal anti-inflammatory drugs (NSAIDS) strong tea or coffees have contributed to the pathology. Our research is based on gastrointestinal secretion and the mechanism of action of PPIs and other acid inhibitors on acid secretion. In the early years, Histamine H2-receptor antagonist, Sucralfate and Muscarinic receptor antagonists were used more often. But with the introduction of the proton pump inhibitors (PPIs) their use has declined owing to the potent anti-secretory and anti-ulcer activity of the PPIs. We published the work on new proton pump inhibitor, esomeprazole, Astra-Zeneca (accepted for publication (2008)). At present we are Studying the interactions of natural products and New Histamine H4 antagonists on Gastric acid and Ulcer formation in the rat in vivo and in vitro. In the near future we are planning to study the effect of stress on the mucosa of FSL and FRL rats and the healing rate of alcohol-and indomethacin-induced ulcers in the same rats. We have received grant to study the effects of TNF alpha on inflammatory parameters in rat intestine

 

  1. Teratology: Epilepsy affects approximately 1% of the world’s population and it is the second most common neurologic disorder after stroke. It is a heterogeneous symptom complex—a chronic disorder characterized by chronic seizures. Approximately 0.5% of all pregnancies occur in women with epilepsy. It is known that epileptic women demonstrate a higher liability to obstetric complication than non-epileptic females and congenital malformations are more common in their offsprings than those of normal or rats. We have published a number of papers on AED.

 

  1. Pharmacogenetics: Initially we worked on acetylation phenotyping since this kind of work had not been done in this part of the world. We published two papers on NAT phenotyping and genotyping (Publication no 6 and 7) in pharmacogenetics. Oxidation by enzymes encoded at the CYP2D6 locus is the main route of elimination for a large number of drugs including many commonly prescribed in psychiatric practice such as antidepressants and neuroleptics. The CYP2D6 locus is highly polymorphic and numerous mutant CYP2D6 alleles are currently known including defective alleles which yield no functional protein product and duplicated active alleles which cause ultrarapid oxidation. Two CYP2D6 oxidation phenotypes EM (extensive metabolisers) and PM (poor metabolisers) are commonly recognized.   These phenotypes can be accurately predicted by genotyping. The clinical implications of the CYP2D6 polymorphism are of potential importance to psychiatric practice in the UAE since tricyclic antidepressants are widely prescribed for treatment of depression.  These drugs have a small therapeutic index and unpleasant side-effects or therapeutic failure is commonly encountered when fixed dose regimens are used.  There are only very few and conflicting data concerning the distribution of CYP2D6 phenotypes in Arab populations and no genotyping studies have ever been carried out. We aim to determine the frequency of the most common CYP2D6 alleles in the local population using allele specific PCR methodology and to assess the relevance of the CYP2D6 polymorphism to psychiatric practice in the UAE.Paper has been pubished.
  2. Recently I have Started doing studies on the effects of Diabetes on gastric morphology and functions.

Membership of FMHS

Committees                            Conference andLeave of Absence Committee (95-96)(2009 to date)
                                                Researchethics subcommittee (92-94)
Faculty Evaluation Committee (2000)
Working group on strategic planning and communication (2001).
Research Grant Evaluation Committee (2001)
FMHS Research Grant Committee (2007-08)
Member of the Scientific Committee for Sheikh Hamdan Bin Rashid Award (2000-)
Chairman for Subcommittee of HH Hamadan Award for Humanitarian Work in Medical Fields (2000- )
Member Research Grant committee (2006-2008)

MOH Committees                

  • Member of Drug Registration Committee (1985-2008)
  • Member of Drug Screening Committee (1985-2004)

  • Member of the Herbal committee (1985-2002)
    Member of Homeopathy committee (1985-2002)
    Ethics Committee of UAE, 1994-1996
    Use of Antibiotic Committee 1994-1998
    Member Special drug Committee (2008-now) 

Other activities:                    

Vice President of the Pharmacy Association of the UAE
Founding member- Emirates Medical Association
Member of Emirates Pharmaceutical Association.
Member of Emirates Pharmaceutical Scientific Committee.
Member Editorial Board of EMJ.
Chairman of Committee of Sheikh Hamdan Awards for Humanitarian Volunteer work in Medical fields
Member of the Organizing and Scientific Committee for International Genetic conference and Chairman of the Social Committee for the same Conference 28-30th October, 2008
Was the Chairman of the Committee for Social activities for guests attending the first Cardiology Conference in Al Ain, 2001.

Supervision of Undergraduate students Research during Summer:

1. Summer of 2007, Titled “Resistance patterns of bacterial isolates to antimicrobials from 3 hospitals in the United Arab Emirates. (2007-2008) published in Saudi Medical Journal, 2009; 30: 618-623.

2. Supervised summer of 2008-2009, research titled, “Protective effect of Nigella Sativa, garlic and onion on gastric ulcer induced by acidified ethanol. Two abstracts were presented one at the UEGW/WGO Gastro 2009, 21-25th of November 2009. Gut, 2009, 58 (suppl): A 271 and the second at 6th International Medical Students Conference in Al Ain, 2009.

3. Supervision of Medical Students 2006-2007 Titled ‘Effects of turmeric on inflammatory mediators in the small intestines of rats’.Presented an abstract Bastaki SMA, Naheed Amir and Adeghate E: Effects of turmeric on serum Il-23 levels and histological parameters in acetic-acid-induced inflammatory Bowel Disease in rats. J Gastroenterol Hepatol, 2010; 25: Meeting of the Asian Pacific Digestive Week, 19-22 September, 2010 in Kaula Lumpur, Malasia.

Editorial Board Member

Publications:-Published 31 full papers
Abstracts 36
Review-8        
Drug updates-47

 

 

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