Profile of Prof. Christian Sebesta

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Curriculum Vitae
Christian Sebesta  M.D.
Head of the 2nd Dep. of Medicine

 

Current position                              Head of the 2nd Department of Internal Medicine
Donauspital Vienna; Academic Teaching Hospital of the Medical University Vienna

Medical qualification

Degrees                                             
1985                                                      MD Degree University of Vienna

1992                                                      Consultant for Internal Medicine and
Senior Physician 2nd Dep.of Internal Medicine, Donauspital

1994                                                      Substitution of the Head of the Department (Prof.Hinterberger)
Additive Consultant for Gastroenterology, Hepatology, Haematology and Oncology

2001                                                      Head of the 1st Medical Department of the Public Hospital of Stockerau

2002                                                      Medical Director of the Public Hospital of Stockerau and
Head of the hospitals in Korneuburg and Stockerau - Humanis-Klinikverbund

2003                                                      Medical Director of the Donauspital  of Vienna
                                                               (2005 – Donauspital Vienna –Academic Teaching Hospital of the Medical University Vienna)

2010                                                      Head of the 2nd Dept. of Internal Medicine, Donauspital

Research associations
2010                                                      Head of the Ludwig Boltzmann Institute for Stem Cell Transplantation Cluster Translational Oncology Vienna

2010                                                      Secretary of “Science Center Donaustadt”           

2011                                                      Head of the school of nursing practice (patient care)

 

                                                                 
Postgraduate education                              
1992 – 2001                                         Residency Internal Medicine (Chairman: W. Hinterberger)
Donauspital Vienna
1996 - 1998                                          Fellowship: Hematology and Oncology (Chairman: W. Hinterberger)
Donauspital Vienna
1985                                                       Radcliff Infirmary in Oxford
1985                                                       Charité Berlin
1992                                                       Klinikum Rechts der Isaar in München
1993                                                       Klinikum Eppendorf in Hamburg

Current Research Projects                                          

Since 2002                                          Minimal residual disease in colorectal cancer: evaluating immunoctochemistry in bone marrow and CK20 RT PCR in bone marrow peripheral blood and correlation with clinical outcome
2004                                                      Monitoring apoptosis and necrosis during adjuvant therapy of solid tumors

Voluntary Work

1985 – 1993                                        Work with children in need of social care

1992 – 2001                                        Head of the Postgraduate Austrian Medical Society-program

Grants                                                 “Forschungsentwicklungspreis der Stadt Wien für Interdisziplinäre Krebsforschung” 2003

               
Teaching                                              Since 2004 Visiting Professor of the Med. University Vienna
as Head of the Clinical Tertials

Special Courses/Training

2003                                                       Certificate: Physician in Emergency Medicine

2004                                       Abdominal Ultrasound in Internal Medicine

Professional                                      Austrian Society of Internal Medicine
memberships                                    Austrian Society of Hematology and Oncology
Austrian Society of Gastroenterology and Hepatology   

Founder Member of the “Scientific Board”, KAV, Vienna

 

Publications                                       124  Publications in peer reviewed journals (1987 – 2012)
                                                (enclosed,  1991-2012)

 

  1. Scheithauer W, Rosen H, Schiessel R, Schüller J, Karall M, Ernst F, Sebesta C, Kornek G, Hentschel E, Marczell A, Depisch D.
    Treatment of Patients with Advanced Colorectal Cancer with Cisplatin, 5-Fluorouracil and Leucovorin.
    Cancer 1991; Mar 1; 67(5):1294-8
  2. Scheithauer W, Rosen H, Kornek G, Sebesta C, Depisch D.
    Randomized Comparison of Combination Chemotherapy plus Supportive Care with Supportive Care alone in Patients with Metastatic Colorectal Cancer.
    BMJ, 1993 Mar 20, 306(6880): 752-5
  3. Kornek G, Schulz F, Depisch D, Rosen H, Kwasny W, Sebesta C, Scheithauer W.
    A Phase I/II Study of Epirubicin, 5-Fluorouracil and Leucovorin in Advanced Adenocarcinoma of the Stomach.
    Cancer 1993 Apr 1., 71(7):2177-80
  4. Sebesta C, Schmid A, Tiefengraber E, Kier P, Ruckser R, Adler V, Dorner S, Hinterberger W.
    Die Blutung aus dem Gastrointestinaltrakt.
    Der Mediziner, 1993, 34:8-16
  5. Sebesta C, Schmid A, Tiefengraber E, Kier P, Ruckser R, Adler V, Dorner S, Hinterberger W.
    Die gastroösophageale Refluxkrankheit.
    Forum Dr. med. 1993, 9:4-10
  6. Kier P, Huber K, Ruckser R, Habertheuer KH, Bauer K, Höcker P, Kurz M, Tiefengraber E, Sebesta C, Hinterberger W.
    Die Bedeutung der sequentiellen CD-34-Messung vor der Durchführung von Stammzellpheresen.
    (The Value of Sequential CD-34 Measurement for Carrying Out Stem Cell Pheresis)
    Wien-Clin-Wochenschrift 1994; 106(8):238-41
  7. Hinterberger-Fischer M, Kier P, Spona J, Sebesta C, Tiefengraber E, Habertheuer KH, Ruckser R, Schmid A, Kalhs P, Lechner K, Hinterberger W.
    Prolactin: A possible Mediator of Graft Versus Host Disease following Allogeneic Bone marrow Transplantation in Humans. 
    BMT, 1994; 14(3);403 – 406
  8. Scheithauer W, Depisch D, Kornek G, Pidlich J, Rosen H, Karall M, Prochaska M, Ernst A, Sebesta C.
    Randomized Comparison of Fluorouracil and Leucovorin Therapy versus Fluorouracil, Leucovorin and Cisplatin in Patients with Advanced Colorectal Cancer.
    Cancer 1994, Mar 15; 73(6):1562-8
  9. Sebesta C, Dorner S, Hölbling N, Schmid A, Tiefengraber E, Kier P, Ruckser R, Hinterberger W.
    Die Ulcusblutung.
    Der Mediziner, 1994, 1:52-56
  10. Hinterberger W, Habaertheuer KH, Höniger S, Kier P, Ruckser R, Scherz M, Sebesta C.
    Autologe Stammzelltranplantation.
    Österr. Ärztezeitung, 1994, 20:35-39
  11. Schmid A, Sebesta C, Ruckser R, Kier P, Hinterberger W.
    Yersiniose – Kasuistik.
    Forum-Gastroenterologie, 1995; Fallbericht 7
  12. Sebesta C, Hentschel E.
    Das Kurzdarmsyndrom
    Forum Gastroenterologie 1995; Fallbericht 1
  13. Tiefengraber E, Sebesta C, Kier P, Ruckser R, Habertheuer KH, Hinterberger W.
    Die mögliche Rolle der Autotransplantation beim kleinzelligen Bronchuskarzinom.
    (Possible Role of Autotransplantation in Small Cell Bronchial Carcinoma).
    Wien-Med-Wochenschrift, 1995; 145(2-3):50-2
  14. Sebesta C, Tiefengraber E, Kier P, Ruckser R, Habertheuer KH, Schmid A, Hinterberger W.
    Autologous Bone Marrow Transplantation in Intestinal Carcinoma.
    WMW 1995; 145(2-3);47-50
  15. Ruckser R, Kier P, Sebesta C, Kittl E, Kurz M, Selleny D, Höniger S, Scherz M, Habertheuer KH, Zelenka P, Schmid A, Tiefengraber E, Höcker P, Bauer K, Hinterberger W.
    Tandem-Transplantation mit peripheren autologen hämatopoetischen Blutstammzellen in der Behandlung onkologischer und hämatologischer Malignome – Erste Ergebnisse am Donauspital.
    WMW 1995; 145(2-3):41-4, 46-7
  16. Hinterberger W, Adler V, Bauer K, Haberhauer G, Habertheuer KH, Höniger S, Huber K, Kier P, Kittl E, Ruckser R, Scherz M, Schmid A, Sebesta C, Tiefengraber E, Tomasits J.
    Die klinische Bedeutung der autologen Transplantation mit hämatopoetischen Stammzellen bei Leukämien und soliden Tumoeren.
    WMW 1995; (2-3):34-40
  17. Habertheuer KH, Kier P, Ruckser R, Scherz M, Höniger S, Sebesta C, Tiefengraber E, Schmid A, Mandl A, Sterz M, Hinterberger W.
    EDV-unterstützte Organisation der Hochdosistherapie mit Stammzelltransplantation im Donauspital.
    WMW 1995; (2-3):64-66
  18. Habertheuer KH, Kier P, Ruckser R, Scherz M, Höniger S, Sebesta C, Tiefengraber E, Schmid A, Mandl A.
    EDV-unterstützte Organisation der Hochdosistherapie mit Stammzelltransplantation im Donauspital.
    WMW 1995; 145(2-3): 64-5
  19. Sebesta C, Schmid A, Kier P, Ruckser R, Tiefengraber E, Rosen H, Stelzhammer K, Geissler K, Hruby W.
    ERCP and Balloon Dilation is a Valuable Alternative to Surgical Biliodigestive Anastomosis in the Long Common Channel Syndrome in Childhood.
    Endoscopy, 1995, Nov. 27(9):709-10
  20. Scheithauer W, Kornek G, Rosen H, Sebesta C, Marcell A, Kwasny W, Karall M, Depisch D.
    Combined Intraperitoneal plus Intravenous Chemotherapy after Curative Resection for Colonic Adenocarcinom.
    Eur-J-Cancer, 1995, Nov; 31A(12):1981-6
  21. Sebesta C, Clodi PH, Fortunat W, Hinterberger W, Judmaier G, Knoflach P, Krejs GJ, Petritsch P, Renner F, Schiessel R, Walchshofer J, Weiss W.
    Endoskopische Diagnostik und endoluminaler Ultraschall.
    ACO-Consensus-Bericht Magenkarzinom, Mai 1995: 21-25
  22. Jatzko GR, Smola GM, Ferenci P, Judmaier G, Karner-Hanusch J, Samec HJ, Sebesta C, Szinicz G, Wunderlich M.
    Screening, Früherkennung, Primär- und Sekundärprävention
    ACO - Consensus-Bericht Kolorektalkarzinom, Mai 1995: 15-17
  23. Huber KR, Sebesta C, Bauer K.
    Detection of Common Hepatitis C Virus Subtypes with a Third-Generation Enzyme Immunoassay.
    Hepatology 1996, Sep 24(3):471-473
  24. Sebesta C, Rokitansky A, Rosen H, Schmid A, Kier P, Ruckser R, Hinterberger W.
    Reply to Comments from Schreiber et al.
    Endoscopy, 1996; Octo Nr. 8, Vol 28:724-725
  25. Schmid A, Sebesta C, Scherz M, Ruckser R, Kier P, Hinterberger W.
    Chronisch entzündliche Darmerkrankungen – Diagnose und Therapie.
    Arzt & Praxis, 1996; 50(757):1-4
  26. Sebesta C, Weiss W, Schmid A, Gschwantler M, Scherz M, Hartmann G, Ruckser R, Kier P, Hinterberger W.
    Seven-day Low-Dose Triple Therapy with Lansoprazole, Clarithromycin and Metronidazole as a First Line Therapy in Patients with H.pylori-positive Peptic Disorders.
    Helicobacter, 1996; Vol 1 Nr.4:279, AB
  27. Hartmann G, Sebesta C.
    Der Fettleberpatient. Klinik und Management.
    Promed. 1997; 4:44-46
  28. Scherz M, Schmid A, Sebesta C.
    Therapie mit nicht-steroidalen Antirheumatika und Magenschutz.
    Arzt & Praxis, 1997: 781:874-878
  29. Sebesta C, Schmid A, Scherz M, Hartmann G, Lanzenberger F, Stelzig S, Selleny S, Hinterberger W.
    Eradikationstherapie des Helocobacter pylori - Indikationen, Strategien, Kosten-Nutzen-Analyse.
    Intern, Gastroenterologie I, 1997; Jg.3:8-12
  30. Schmid A, Scherz M, Selleny S, Sebesta C.
    Chronisch entzündliche Darmerkrankungen, Diagnostik und Therapie.
    Intern, Gastroenterologie I, 1997; Jg.3: 14-18
  31. Hartmann G, Huber K, Stelzig S, Sebesta C.
    Die Therapie der chronischen Virushepatitis.
    Intern, Gastroenteroloige I, 1997; Jg.3:19-23
  32. Ruckser R, Sebesta C, Kier P, Schmid A, Zelenka P, Kittl E, Hinterberger W.
    Magenkarzinom.
    Intern, Gastroenterologie II, 1997; Jg.4:10-14
  33. Scherz M, Schmid A, Hartmann G, Lanzenberger F, Ruckser R, Selleny S, Sebesta C.
    Kolorectales Karzinom, Screening, Endoskopische Diagnostik.
    Intern, Gastroenterologie II, 1997; Jg.4: 15-19
  34. Hinterberger W, Sebesta C.
    Die konservative Therapie des kolorektalen Karzinoms.
    Intern, Gastroenterologie II, 1997; Jg. 4:20-23
  35. Schmid A, Sebesta C, Hartmann G, Scherz M,. Frey S, Hinterberger W.
    Chronisch entzündliche Darmerkrankungen: Morbus Crohn und Colitis Ulcerosa.
    Turn to us 1997; 1. Jg. (1):3-5
  36. Huber K, Bittner J, Bauer K, Trümper L,Sek A, Sebesta C, Rosen H, Tragl KH.
    Restriction Digest PCR (RD-PCR) for the Analysis of Gene Mutations. Application to Ki-ras.
    Clin Chem Lab Med 1998; 36(8):593-595
  37. Thomsen O, Cortot A, Jewell D, Wright J, Winter T, Veloso F, Vatn M, Persson T, Petersson T, Sebesta C.
    A Comparison of Budesonide and Mesalamine for Active Crohn´s Disease.
    The N Engl J Med, 1998; 339:370-374
  38. Niederau C, et al. Leich Study Group
    Polyunsaturated Phosphatidyl-Choline and Interferon alpha for Treatment of Chronic Hepatitis B and C: A Multicenter, Randomized, Double-Blind, Placebo-Controlled Trail.
    Hepato-Gastroenterology 1998; 45: 797-804
  39. Huber KR, Sebesta C, Worofka B, Kittl E, Hofmann J, Klar S, Hinterberger W, Bauer K.
    Diagnostic Challenges of Hepatitis C Virus Infection.
    Drugs Today (Barc)1998; Jan:34(1):11-15
  40. Neumayer R, Rosen H, Reiner A, Sebesta C, Schmid A, Tüchler H, Schiessel R.
    CD44 Expression in Benign and Malignant Colorectal Polyps.
    Dis-Colon-Rectum 1999; Jan 42(1):50-5
  41. Ferenci P, Stauber R, Steindl-Munda P, Gschwantler M, Fickert P, Datz C, Müller C, Hackl F, Rainer W, Watkins-Riedel T, Lin W. Austrian Hepatitis Study Group.
    Interim Analysis of a Randomized Controlled Trial of Combination of Ribavirin and High Dose Interferon-α in Interferon Nonresponders with Chronic Hepatitis C.
    Journal of Viral Hepatitis 1999; 6 (Suppl.1):53-58
  42. Hinterberger-Fischer M, Ogris E, Kier P, Bauer K, Kittl E, Habertheuer KH, Ruckser R, Schmid a, Selleny S, Fangl M, Sebesta C, Hinterberger W.
    Elevation of Plasma Prolactin in Patients Undergoing Autologous Blood Stem-Cell Transplantation for Breast Cancer.
    Am J Clin Oncol 2000; 23(4):325-329
  43. Sebesta C.
    Chronisch-entzündliche Darmerkrankungen. Teil 1; Klinik, Pathogenese und diagnostische Möglichkeiten bei Colitis Ulcerosa und Morbus Crohn.
    Ärztemagazin 2000; 37 (16.Sept): 16-18
  44. Sebesta C.
    Chronisch-entzündliche Darmerkrankungen. Teil 2: Differentialtherapeutische Möglichkeiten bei Colitis ulcerosa und Morbus Crohn.
    Ärztemagazin 2000; 38(23.Sept): 14-16
  45. Kier P, Ruckser R, Buxhofer V, Habertheuer KH, Zelenka P, Tatzreiter G, Hübl G, Kittl E, Hauser A, Sebesta C, Hinterberger W.
    Hochdosistherapie und autologe periphere Stammzelltransplantation beim Mammakarzinom.
    AMA 2000; 27 (Suppl.52):33-36
  46. Buxhofer V, Ruckser R, Kier P, Zelenka P, Tatzreiter G, Dorner S, Vedovelli H, Sebesta C, Hinterberger W.
    Hochdosistherapie mit Stammzelltransplantation beim neuroendokrinen Karzinom in Stammzelltransplantation.
    AMA 2000; 27 (Suppl.52):37-39
  47. Sebesta C.
    Diagnose von CED. Bedeutung von Endoskopie, Sonographie und Radiologie.
    ÖKZ 2000; 41, 1: Sonderteil 2
  48. Kittl E, Hoffmann J, Hartmann G, Sebesta C, Beer F, Bauer K, Huber KR.
    Serum Protein 90K/Mac-2BP is an Independent Predictor of Disease Severity during Hepatitis C Virus Infection.
    Clin Chem Lab Med 2000; 38(3):205-208
  49. Sebesta C.
    Hepatitis C: Editorial
    WMW 2000; 150(23-24):459
  50. Hartmann G, Ramadar B, Hübl G, Sebesta C.
    Klinik und Verlauf der extrahepatischen Manifestationen der Hepatitis C.
    WMW 2000; 150, 23/24:467-471
  51. Huber K, Kittl E, Sebesta C, Bauer K.
    Labordiagnostik bei Hepatitis C-Virus-Infektion.
    WMW 2000; 150, 23/24:472-475
  52. Buxhofer V, Ruckser R, Kier P, Habertheuer KH, Tatzreiter G, Zelenka P, Dorner S, Sebesta C, Knosp E, Hruby W, Hinterberger W.
    Successful Treatment of Invasive Mould Infection Affecting Lung and Brain in an Adult Suffering from Acute Leukaemia.
    Eur J Haematol 2001; Aug:67(2):128-132
  53. Ferenci P, Stauber R, Steindl-Munda P, Gschwantler M, Fickert P, Datz C, Müller C, Hackl F, Rainer W, Watkins-Riedel T, Lin W, Krejs G, Gangl A for the Austrian Hepatitis Study Group
    Treatment of Patients with Chronic Hepatitis C not Responding to Interferon with High-Dose Interferon Alpha with or without Ribavirin: Final Results of a Prospective Randomized Trial.
    European Journal of Gastroenterology & Hepatology, 2001; Vol 13:699-705
  54. Ferenci P, Brunner H, Nachbauer K, Datz C, Gschwantler M, Hofer H, Stauber R, Hackl F, Jessner W, Rosenbeiger M, Munda-Steindl P, Hegenbarth K, Gangl A, Vogel W for the Austrian Hepatitis Study Group
    Combination of Interferon Induction Therapy and Ribavirin in Chronic Hepatitis C.
    Hepatology 2001; Vol 34 No 5:1006-1011
  55. Urban M, Holzer B, Sebesta C, Schmid L, Schiessel R, Hruby W, Rosen H.
    Efficacy of Diagnosis of Mechanical Cholestasis by Magnetic Resonance Cholangiography.
    World J Surg 2002; Mar; 26(3):353-358. Epub 2002 Jan 15.
  56. Sebesta C.
    The Significance of Helicobacter Pylori Infection from the Clinical Viewpoint.
    Wien Med Wochenschr.2002; 152(5-6):115. German
  57. Sebesta C, Höller E, Györög M, Prenner M, Trianto T, Klammer I, Willmann A, Maderbacher H.
    Therapy of Helicobacter Pylori Infection: „Who to treat, how to treat?“
    Wien Med Wochenschr 2002; 152(5-6):141-7
  58. Cozzarini W, Rath J, Bauer a, Györög I, Györög M, Prenner M, Trianto T, Maderbacher H, Höller e, Grusch B, Sebesta C.
    Mucosa Protective Therapy with Long-Term Nonsteroidal Antirheumatic Drugs.
    Wien Med Wochenschr 2003; 153(13-14): 295-303 Review German
  59. Hinterberger W, Buxhofer V, Dorner S, Bach-Parth E, Kier P, Ruckser R, Zelenka P, Schmid I, Habertheuer KH, Vedovelli H, Tatzreiter G, Fangl M, Vyhnlik M, Stampfl M, Racz I, Ogris E, Schmid A, Scherz M, Sasse D, Sebesta C, Geissler K, Hinterberger-Fischer M.
    The present Spectrum of Therapies for Severe Aplastic Anaemia (SAA)
    17. Meeting of Intern.Society of Haematology, Graz, 7.-10.September 2003
    International Society of Haematology, 2003, Monduzzi Editore:109-112
  60. Buxhofer-Ausch V, Ruckser R, Kier P, Habertheuer KH, Zelenka P, Tatzreiter G, Ausch C, Schmid I, Hruby W, Reiner-Concin A, Sebesta C, Ogris E, Hinterberger-Fischer M, Hinterberger W.
    A Rare Case of Interstitial Pneumonitis after Tandem High-Dose Melphalan Conditioning and Autologous Stem Cell Transplantation in Multiple Myeloma.
    Eur J Haematol 2004; 73:143-146
  61. Ausch C, Hochwarter G, Taher M, Holzer B, Rosen HR, Urban M, Sebesta C, Hruby W, Schiessel P.
    Improving the Safety of Laparoscopic Cholecystectomy: The Routine Use of Preoperative Magnetic Resonance Cholangiography.
    Surg Endosc.2005; Apr.19(4):574-80. Epub 2005 Mar 11   
  62. Ferenci P, Laferl H, Scherzer TM, Gschwantler M, Maieron A, Brunner H, Stauber R, Bischof M, Bauer B, Datz C, Löschenberger K, Formann E, Staufer K, Steindl-Munda P for the Austrian Hepatitis Study Group
    Peginterferon Alfa-2a and Ribavirin for 24 Weeks in Hepatitis C Type 1 and 4 Patients With Rapid Virological Response.
    Gastroenterology 2008; 135:451-458
  63. Ferenci P, Brunner H, Laferl H, Scherzer TM, Maieron A, Strasser M, Fischer G, Hofer H, Bischof M, Stauber R, Gschwantler M, Steindl-Mund P, Staufer K, Löschenberger K fort he Austrian Hepatitis Study Group
    A Randomized, Prospective Trial of Ribavirin 400 mg/Day Versus 800 mg/Day in Combination with Peginterferon Alfa-2a in Hepatitis C Virus Genotypes 2 and 3.
    Hepatology 2008; 47:1816-1823
  64. Mostafaie N, Huber KR, Sebesta C, Bauer K, Kristoferitsch W, Volc-Platzer B, Kurz H, Klinghofer I, Mirkovic B, Hofmann J, Hejtmann M, Schrattbauer K, Krugluber W.
    Diagnosis of Infection with Human Herpes Viruses in Routine Labarotory Practice.
    Clin Chem Lab med.2009, Jul 27
  65. Ross RS, Viazov S, Khudayakov YE, Xia GL, Lin Y, Holzman H, Sebesta C, Roggendorf M, Janata O.
    Transmission of Hepatitis C Virus in an Orthopedic Hospital Ward.
    J Med Virol.2009; Feb.81(2):249-57
  66. Mostafaie N, Sebesta C, Zehetmayer S, Jungwirth S, Huber KR, Hinterberger M, Leitha T, Hofman J, Hejtman M, Schrattbauer K, Krugluger W, Tragl KH, Fischer P.Circulating retinol-binding protein 4 and metabolic syndrome in the elderly. Wien Med Wochenschr. 2011 Nov;161(21-22):505-10. Epub 2011 Apr 4.
  67. Sédille-Mostafaie N, Sebesta C, Huber KR, Zehetmayer S, Jungwirth S, Tragl KH, Fischer P, Krugluger W. The role of memory-related gene polymorphisms, KIBRA and CLSTN2, on replicate memory assessment in the elderly.  Neural Transm. 2012 Jan;119(1):77-80. Epub 2011 Jun 4.
  68. Bartsch R, Freissmuth M, Gastl G, Lang A, Marth C, Mineritsch B, Petzer A, Ruckser R, Sebesta C, Sevelda P, Singer C, Steger G, Stöger H, Zielinski C.
    Albumin-Paclitaxel: ein neues Zytostatikum mit Wirksamkeits- und Verträglichkeitsbenefits- Experten-Statements.
    Med ahead, März 2012
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