Profile of Von Herrath, Matthias, MD

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Name:von Herrath, Matthias, MD  Prof. Von Herrath, Matthias, MD    
eRA COMMONS USER NAME:HERRATH

POSITION TITLE:

Professor/Director Type 1 Diabetes Center
La Jolla Institute for Allergy and Immunology 

EDUCATION/TRAINING 
  
INSTITUTION AND LOCATION YEAR(s) FIELD OF STUDY
Freiburg Medical School, Freiburg, Germany 08/88 Medicine
Freiburg Medical School, Freiburg, Germany
(PhD equivalent
10/82-05/88 Biochemistry
(summa cum laude)
Freiburg Medical Center, Freiburg, Germany 05/88-05/89 Medicine/Immunology
Diakonie Hospital, Freiburg, Germany 05/89-02/91 Intensive Care residency
Scripps Research Institute, La Jolla, CA 02/91-06/95 Virology
 
A. Personal Statement
 
My research program is translational in nature and my dream is to see some of the immune based interventions we discovered in animal models translated to improve human health. We are focused on dissecting how autoantigen-induced regulatory T cells (Tregs) act in immune-competent hosts in vivo and how they can be used in the clinic to prevent type 1 diabetes. In this context we were the first to describe that insulin B chain-expressing DNA vaccines can prevent diabetes in animal models through induction of such Tregs (Coon et al. JCI 1999 and Homann Immunity 1999), an approach that has borne initial promise now in clinical trials (BayHill Therapeutics). Another key project has been the development of combination therapies aimed at reversing recent onset type 1 diabetes. The therapy has shown promise in mouse models and involves using a combination of a vaccine to stimulate Tregs and an immune modulator (anti-CD3 or anti-CD20) that dampens autoaggressive T cells and facilitates the induction of Tregs. More basic research projects analyze the regulation of autoimmune injury and anti-viral responses. Specifically, my laboratory investigates the role of key cytokines (TGF-beta, IL-4/IL-5 and IL-10), transcription factors (T-bet) and chemokines (IP-10) in regulating autoimmunity and virally-induced immunopathology in chronic viral infections. It is my hope that paradigms developed from these studies will not only be useful in selectively suppressing autoimmune diseases, but can also be employed to lower immunopathology that accompanies viral infections such as Hepatitis C virus and HIV.
 

B. Positions and Honors

1995-96 Sr. Res. Associate, Dept. of Neuropharmacology, Scripps Research Institute, La Jolla, CA
1996-99  Assistant Professor, Dept. of Neuropharmacology, Scripps Research Institute, La Jolla, CA
1999-2001 Associate Professor, Dept. of Neuropharmarmacology, Scripps Research Institute, La Jolla
2001- Adjunct Associate Professor, Dept. of Molecular and Experimental Medicine, Scripps Research Institute, La Jolla, CA
2001-05 Associate Member with Tenure, La Jolla Institute of Allergy and Immunology, La Jolla, CA
2004- Adjunct Professor, Dept. of Pediatrics, University of California, San Diego, CA
2005- Associate Professor, La Jolla Institute for Allergy and Immunology, La Jolla, CA
2008 Professor and Director for Type 1 Diabetes Research Center, LIAI, La Jolla, CA

Awards and Fellowships:

1986: DAAD Fellowship; 1991-93: DFG Fellowship; 1993-95 Juvenile Diabetes Foundation Fellowship; 1996-2000 Juvenile Diabetes Foundation Career Development Award; 2001    George Köhler Award, German Society of Immunology, 2006 JDRF Grotzky Award,   2008 American Diabetes Association – Outstanding Scientist Achievement award

 

U.S. citizen

C.  Selected Publications (15 most relevant)         

  • Sanda, S., Roep, B.O., and von Herrath, M.G. Islet antigen specific IL-10+ immune response but not CD4+FoxP3+ cells at diagnosis predict glycemic control in type 1 diabetes. 2008 Clin Immuno  May;127(2):138-43.  PMCID:  N/A.
  • Van Belle, T., von Herrath, M.G. Immunosuppression in islet transplantation. 2008 J Clin Invest May;118(5):1625-8. PMCID: PMC2323197.Filippi, C., and von Herrath, M.G. Viral trigger for type 1 diabetes. 2008 Diabetes Nov;57(11):2863-71. PMCID: PMC2570378
  • von Herrath, M.G. Can we learn from viruses how to prevent type 1 diabetes?: the role of viral infections in the pathogenesis of type1 diabetes and the development of novel combination therapies. 2009 Diabetes Jan;58(1):2-11. PMCID: PMC2606872
  • Fousteri, G., Dave, A., Juntti, T., and von Herrath, M.G. CD103 is dispensable for anti-viral immunity and autoimmunity in a mouse model of virally-induced autoimmune diabetes 2009 J Autoimmun Feb;32(1):70-7. PMCID: PMC2706207
  • Filippi, C., Estes, E.A., Oldham, J.E., and von Herrath, M.G. Immunoregulatory mechanisms triggered by viral infections protect from type 1 diabetes in mice. 2009 J Clin Invest June;119(6):1515-23. PMCID: PMC2689128
  • von Herrath, M.G. Diabetes: A virus-gene collaboration. Nature 2009 May 28;459(7246):518-9. REVIEW PMCID: N/A
  • Bresson, D., Fradkin, M., Manenkova, Y., Rottembourg, D., and von Herrath, M.G. Genetic-induced variations in the GAD65 T cell repertoire governs efficacy of anti-CD3/GAD65 combination therapy in new-onset type 1 diabetes. 2009 Mol Ther  Aug 18. PMCID: PMC2818225
  • von Herrath, M.G. and Chan, A.  How can we improve the translational landscape for a faster cure of type 1 diabetes? J Clin Invest  2009 May;119(5):1061-5. PMCID: PMC2673858
  • Sutherland AP, Van Belle T, Wurster AL, Suto A, Michaud M, Zhang D, Grusby MJ, von Herrath M. G. Interleukin-21 is required for the development of type 1 diabetes in NOD mice. Diabetes 2009  May;58(5):1144-55. PMCID: PMC2671036
  • Filippi, C., Estes, E.A., Oldham, J.E., and von Herrath, M.G. Immunoregulatory mechanisms triggered by viral infections protect from type 1 diabetes in mice.  J Clin Invest  2009 Jun;119(6):1515-23. PMCID: PMC2689128
  • Fousteri, G., Chan, J.R., Zheng, Y., Whiting, C., Dave, A., Bresson, D., Croft, M. and von Herrath, MG. Virtual optimization of nasal insulin therapy predicts immunization frequency to be crucial for diabetes protection. Diabetes 2010 Sep 23. PMCID: PMC2992777 [Available on 2011/12/1]
  • Martinic MM, Huber C, Coppieters K, Oldham JE, Gavin AL, von Herrath MG. Expression level of a pancreatic neo-antigen in beta cells determines degree of diabetes. J Autoimmu 2010 Oct 5. PMCID: PMC2963714 [Available on 2011/12/1]
  • Coppieters K, Martinic MM, Kiosses WB, Amirian N, and von Herrath MG. A novel technique for the in vivo imaging of autoimmune diabetes development in the pancreas by two-photon microscopy. PLoS-ONE 2010 Dec 23;5(12):e15732. PMCID: PMC3009738
  • Fousteri G, Dave A, Juedes A, Juntti T, Morin B, Togher L, Farber, DL, and von Herrath, MG. Increased memory conversion by naïve CD8 T cell activated during late phase of acute virus infection. 2011 PLoS-One Jan 6;6(1):e14502 PMID: PMC:3017078
  • Bresson D, von Herrath MG. Anti-thymoglobulin (ATG) treatment does not reverse type 1 diabetes in the acute virally induced rat insulin promoter-lymphocytic choriomeningitis virus (RIP-LCMV) model. Clin Exp Immunol 2011 Jan 14 (10) 1365-2249. PMID:21235534 
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