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Year : 2012  |  Volume : 5  |  Issue : 2  |  Page : 189-190

Additional and prolonged anticoagulation in patients with acute coronary syndrome? The ATLAS ACS 2-TIMI 51 trial


Professor of Cardiology, Vienna Medical School, Vienna, Austria

Correspondence Address:
Alexander Niessner
Professor of Cardiology, Vienna Medical School, Vienna
Austria
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Source of Support: None, Conflict of Interest: None


DOI: 10.7707/hmj.v5i2.172

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The additional application of low-dose rivaroxaban twice daily to standard therapy showed improved efficacy in patients with acute coronary syndrome (ACS) in the ATLAS ACS 2-TIMI 51 (anti-Xa therapy to lower cardiovascular events in addition to standard therapy in subjects with acute coronary syndrome thrombolysis in myocardial infarction) study. All-cause mortality was even reduced with 2×2.5 mg rivaroxaban. However, increased efficacy was associated with worse safety with, most importantly, an increased rate of intracranial bleeding.


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