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Year : 2017  |  Volume : 10  |  Issue : 3  |  Page : 163-167

Serum interleukin 8 level is linked to the inflammatory and cardiometabolic indicators in survivors of breast cancer

1 Department of Pharmacology, College of Pharmacy, Erbil, Iraq
2 College of Health Sciences, Hawler Medical University, Erbil, Iraq

Correspondence Address:
Marwan Salih Mohammad Al-Nimer
Department of Pharmacology, College of Pharmacy, Hawler Medical University, Erbil
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Source of Support: None, Conflict of Interest: None

DOI: 10.7707/hmj.676

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Serum interleukin 8 (IL-8) levels have been shown to increase in post-relapse survivors of breast cancer, and its levels are linked with a poor prognosis and progression of breast tumours. This study aims to assess serum IL-8 levels and the components of metabolic syndrome in breast cancer survivors, taking into consideration their menopausal status. This observational study was carried in Nanakali Hospital in Erbil, Kurdistan. A total of 120 women with a history of breast cancer were enrolled and divided into premenopausal (group I, n = 30) and postmenopausal (group II, n = 90) groups. Cardiometabolic determinants including body mass index, blood pressure, fasting serum lipids and lipoproteins were measured. Markers that related to breast cancer, including high-sensitivity C-reactive protein (hs-CRP) and IL-8, were determined. Group II patients had significantly higher levels of atherogenic lipids than group I patients. The mean levels of hs-CRP and IL-8 were significantly higher in group II {3.040 mg/l [standard deviation (SD) ± 0.762] and 424.7 pg/ml (SD ±87.3 pg/ml), respectively} than in group I [2.435 mg/l (SD ±0.891) and 354.6 pg/ml (SD ±109.4), respectively] patients. We conclude that postmenopausal women with breast cancer are at a significant risk of dyslipidaemia and have higher levels of inflammatory and pro-tumorigenic factors than premenopausal women.

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