Incidence of treatable retinopathy of prematurity in twin tertiary care government hospitals in dubai and its management

Sivakami A Pai; Afra M Lootah; Muhammad Fazal; Manal O Taryam; Mahmoud S Elhalik; Mohammed Atif Makdum; Budoor A Alamimi; Mohamed Kannas; Laila M Almuhiri; Moza A Dekhain

doi:10.4103/HMJ.HMJ_21_18

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ORIGINAL ARTICLE

Year : 2018 \| Volume : 11 \| Issue : 2 \| Page : 56-64

Incidence of treatable retinopathy of prematurity in twin tertiary care government hospitals in dubai and its management Sivakami A Pai¹, Afra M Lootah², Muhammad Fazal², Manal O Taryam³, Mahmoud S Elhalik⁴, Mohammed Atif Makdum², Budoor A Alamimi², Mohamed Kannas⁵, Laila M Almuhiri⁶, Moza A Dekhain⁷ ¹ Department of Ophthalmology, Al Zahra Private Hospital, Dubai, United Arab Emirates ² Department of Ophthalmology and Neonatology, Dubai Hospital, Dubai, United Arab Emirates ³ Department of Ophthalmology, Dubai Health Authority, Dubai, United Arab Emirates ⁴ Department of Neonatology, Latifa Hospital, Dubai, United Arab Emirates ⁵ Department of Ophthalmology, Emirate International Hospital, Al Ain, United Arab Emirates ⁶ Department of Neonatology, Garhoud Private Hospital, Dubai, Dubai, United Arab Emirates ⁷ Department of Neonatology, Dr. Sulaiman Al Habib Hospital, Dubai, United Arab Emirates Correspondence Address: Sivakami A Pai Al Zahra Private Hospital, Dubai United Arab Emirates Source of Support: None, Conflict of Interest: None DOI: 10.4103/HMJ.HMJ_21_18

Aim: The purpose of this study was to estimate the present incidence of Treatable Retinopathy of prematurity (ROP) in Dubai. To share our experience following bevacizumab monotherapy for treatable ROP. Design: It is a prospective nonrandomized, interventional case series. Method: Infants of two major government hospital in Dubai, Latifa hospital and Dubai Hospital, Neonatal Intensive care unit (NICU) were screened for Retinopathy of prematurity (ROP). ROP screening was based on American Academy of Pediatrics (AAP) guidelines. The Inclusion Criteria for treatable ROP were the infants with Type 1 ROP; Stage 2 plus and Vascular stage 3 plus ROP in zone I and II disease. Intravitreal injection of 0.75 mg/0.03 ml bevacizumab was given under topical anesthesia. The follow up period was from 6 months to 1 year after the treatment. Results: Eight hundred and ten premature infants were screened from April 2010 to April 2014. Among them 215 had ROP (26.54%). One hundred and twelve eyes of 56 neonates (6.9%) developed treatable ROP. Ninety- four eyes of 47 infants underwent bevacizumab monotherapy. In 92.6% eye the ROP regressed. There was recurrence of ROP in 7.4%. Conclusion: The incidence of pre-term births is rising in Dubai due to increase in the population and fertility treatment trend in Dubai. Anti-VEGFs are effective treatment for vascular ROP with back up laser being mandatory. However, long term effects of Anti-VEGFs on neuro motor development needs to be monitored



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