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Year : 2018  |  Volume : 11  |  Issue : 4  |  Page : 144-150

Hope for escape from a prison of bone: Cellular and molecular targets for fibrodysplasia ossificans progressiva

Department of Orthopaedic Surgery, Medicine, The Center for Research in FOP and Related Disorders, The Perelman School of Medicine, The University of Pennsylvania, Philadelphia, PA, USA

Correspondence Address:
Prof. Frederick S Kaplan
Division of Orthopaedic Molecular Medicine, Department of Orthopaedic Surgery, Penn Musculoskeletal Center, The Perelman School of Medicine, The University of Pennsylvania, Suite 600, 3737 Market Street, Philadelphia, PA 19104
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/HMJ.HMJ_78_18

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The progressive pathological metamorphosis of one normal organ system into another is unique to fibrodysplasia ossificans progressiva and unveils a pathophysiologic process that can be exploited for therapy of disabling extraskeletal ossification. Here, we review the recent remarkable insight from medical research and the potential of targeted therapy for this rare condition as well as for many common forms of heterotopic ossification.

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