| ORIGINAL ARTICLE |
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| Year : 2020 | Volume
: 13
| Issue : 3 | Page : 150-155 |
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Acid-neutralising capacity and pharmacoeconomic studies of commercially available antacids in the Qassim Region of Saudi Arabia
Danish Mahmood1, Sulaiman Alnaseer1, Bala Yauri Muhammad1, Habibullah Khalilullah2, Mahfoudh A M Abdulghani1, Md Jamir Anwar1, Sattam K Alenezi1, Mohammad Haider1, Nasra Elleban1
1 Department of Pharmacology and Toxicology, Unaizah College of Pharmacy, Unaizah, Qassim University, Qassim, Saudi Arabia
2 Department of Pharmaceutical Chemistry and Pharmacognosy, Unaizah College of Pharmacy, Unaizah, Qassim University, Qassim, Saudi Arabia
Correspondence Address:
Danish Mahmood
Department of Pharmacology and Toxicology, Unaizah College of Pharmacy, Qassim University, Al Qassim
Saudi Arabia
 Source of Support: None, Conflict of Interest: None
DOI: 10.4103/HMJ.HMJ_10_20
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Background: Antacids are common over-the-counter medications for relief in common dyspeptic symptoms. However, antacid use has decreased with the availability powerful acid suppressant medications such as histamine H2 blockers, proton-pump inhibitors and prostaglandin analogues. Of late, a resurgence in the usage of antacids has been noted because of the improved profiles of newer antacid formulations, for example, the addition of pain-relieving component, oxetacaine (a local anaesthetic), anti-flatulent (alginate base compounds), in some antacid preparations. Aims and Objectives: The study investigated the efficacy (in terms of acid-neutralising capacity [ANC]) and cost-effectiveness of commercially available antacid formulations (both liquid and solid formulations). Materials and Methods: ANC was carried out using simple titrimetric methods and cost-effectiveness of antacid preparations was based on cost (in Saudi riyal) per milliequivalents of the acid neutralised. Results: ANC/gram was highest for antacid A1 (Moxal Plus solid) and lowest for antacid A3 (Fawar effervescent powder). The ANC/gram varied greatly among different antacid products and it ranged from 3.48 to 13.18. In general, solid antacids showed a high ANC/gram compared to the liquid antacids. Furthermore, solid antacids were also found to be cost-effective compared to liquid dosage forms. In terms of efficacy, the newer antacid containing simethicone (A1) was found to be more cost-effective followed an antacid containing calcium carbonate (A2) and magnesium carbonate. Conclusion: In conclusion, mentioning ANC on antacid formulation labels may help to guide the choice of appropriate antacid, while cost-effectiveness study would govern the prescribing pattern of an antacid.
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