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ORIGINAL ARTICLE
Year : 2021  |  Volume : 14  |  Issue : 4  |  Page : 172-178

Acute kidney injury in COVID-19 patients – Dubai Hospital experience: Incidence, risk factors and outcome


Department of Nephrology, Dubai Health Authority, Dubai Hospital, Dubai, United Arab Emirates

Correspondence Address:
Kashif Gulzar
Department of Nephrology, Dubai Health Authority, Dubai Hospital, Dubai
United Arab Emirates
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/hmj.hmj_21_21

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Background: The key features of coronavirus disease 2019 (COVID-19) are diffuse alveolar damage and lung failure and also kidney and other organ involvements are reported. However, renal complications are not well explored yet. Aim: In this study, we report distinctive experience with acute kidney injury (AKI) in COVID-19 patients and provide its incidence, risk factors and outcome to improve understanding of this complication. Methods: This retrospective cohort study was conducted in Dubai Hospital from 1 April 2020 to 4 June 2020. We analyse 586 COVID-positive admitted patients' data. Information regarding demographics, comorbidities, medications, clinical and laboratory data and outcomes was collected from patients' electronic medical records. Multivariate analyses were performed to determine the association of AKI with inhospital mortality. Results: The median age was 48.30 (21–92) years; more than 88% of the patients were male. One hundred and thirty-five (23.03%) patients developed AKI during hospitalisation. Male sex, haemodynamic instability, mechanical ventilation, acute respiratory distress syndrome, admission high ferritin, creatinine, D-dimer and low absolute lymphocyte count have identified risk factors for inhospital AKI. The mortality rate in the AKI population was 39.86%, and multivariate analyses reveal that age >75 years, creatinine >1.5 mg/dl at admission, mechanical ventilation and AKI Stage 3 are risk factors associated with high mortality. Conclusion: Incidence of AKI in hospitalised COVID-19 patients is high and associated with high mortality, especially in AKI Stage 3. Planning is needed to handle AKI in COVID patients.


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