Correlation of salivary lactate dehydrogenase with histopathological findings and tumor staging of squamous cell carcinomas in the head and neck region Simon P, Shivashankara AR, Tonse R, George T, Rao P, Rao S, Baliga MS, - J Indian Prosthodont Soc

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Correlation of salivary lactate dehydrogenase with histopathological findings and tumor staging of squamous cell carcinomas in the head and neck region Paul Simon¹, Arnadi Ramachandrayya Shivashankara², Raees Tonse³, Thomas George¹, Pratima Rao⁴, Suresh Rao⁵, Manjeshwar Shrinath Baliga⁶ ¹ MBBS Student, Father Muller Medical College, Mangalore, Karnataka, India ² Department of Biochemistry, Father Muller Medical College, Mangalore, Karnataka, India ³ Radiation Oncology, Father Muller Medical College, Mangalore, Karnataka, India ⁴ Department of Orodental Pathology, Mangalore Institute of Oncology, Mangalore, Karnataka, India ⁵ Department of Radiation Oncology, Mangalore Institute of Oncology, Mangalore, Karnataka, India ⁶ Research Unit, Mangalore Institute of Oncology, Mangalore, Karnataka, India Correspondence Address: Arnadi Ramachandrayya Shivashankara, Department of Biochemistry, Father Muller Medical College, Kankanady, Mangalore, Karnataka India Manjeshwar Shrinath Baliga, Research Unit, Mangalore Institute of Oncology, Pumpwell, Mangalore, Karnataka India Source of Support: None, Conflict of Interest: None DOI: 10.4103/HMJ.HMJ_12_20

Background: Lactate dehydrogenase (LDH) is an important enzyme and is recently being investigated in various orodental pathologies. The present study was carried out to investigate whether there is any correlation between LDH with the various histopathological gradings. Materials and Methods: Saliva was collected between 9 and 10 AM from patients of head and neck cancers (HNCs). Concomitantly, saliva was also collected from age matched healthy volunteers for comparing the results of the study population. Saliva collected from both the cohorts were processed and evaluated for LDH levels using standard kit. The data were analyzed using analysis of variance and with Bonferroni multiple comparison. A value of P < 0.05 was considered statistically significant. Results: The results indicate that when compared to the healthy individuals, a significant increase was observed in the salivary LDH of cancer patients (280.55 ± 17.48 vs. 353.58 ± 30.19; P < 0.001). A significant difference was also observed with differentiation, size, nodal status and metastasis (P < 0.0001). Conclusions: The results indicate that salivary LDH is helpful as an adjunct to the standard histopathological grading in the diagnosis and prognosis of HNCs.

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    -  Simon P
    -  Shivashankara AR
    -  Tonse R
    -  George T
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    -  Rao S
    -  Baliga MS

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